13490-76-1

Basic information

• Product Name: (S)-2-phenylbutyramide
• Synonyms: (S)-2-phenylbutyramide
• CAS NO: 13490-76-1
• Molecular Weight: 163.219
• Mol File: 13490-76-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-2-phenylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-phenylbutyramide(13490-76-1)
• EPA Substance Registry System: (S)-2-phenylbutyramide(13490-76-1)

Safety Data

• Hazardous Substances Data: 13490-76-1(Hazardous Substances Data)

Upstream product

• 769-68-6 2-phenylbutanenitrile 
• 4286-15-1 (S)-2-phenylbutyric acid 
• 40473-35-6 (S)-(+)-2-phenylbutyric acid chloride 
• 90-27-7 2-Phenylbutyric acid 
• 90-26-6 2-phenylbutyramide 

Downstream Products

• 90-27-7 2-Phenylbutyric acid 
• 33603-06-4 (+)-1-amino-2-phenylbutane 
• 56652-56-3 (S)-2-phenyl-butyronitrile 
• 1337959-54-2 C₁₁H₁₁NOS₂ 
• 1337959-56-4 C₁₁H₁₁NOS₂ 

Relevant articles and documents

Absolute configuration and polymorphism of 2-phenylbutyramide and α-methyl-α-phenylsuccinimide

Crystal structures of racemic and homochiral forms of 2-phenylbutyramide (1) and 3-methyl-3-phenylpyrrolidine-2,5-dione (2) were investigated in detail by a single crystal X-ray diffraction study. Absolute configurations of the homochiral forms of 1 and 2, obtained by chromatographic separation of racemates, were determined. It was revealed that racemate and homochiral forms of 1 are very similar in terms of supramolecular organization (H-bonded ribbons) in crystal, infrared (IR) spectral characteristics, and melting points. The presence of two different molecular conformations in homochiral forms of 1 allowed mimicking of crystal packing of the H-bonded ribbons in racemate 1. Two polymorph modifications (monoclinic and orthorhombic) comprising very similar H-bonded zigzag-like chains were found for the homochiral forms of compound 2 that were significantly different in terms of crystal structure, IR spectra, and melting points from the racemic form of 2. Unlike compound 1, homochiral forms of compound 2 have a higher density than the corresponding racemate which contradicts the Wallach rule and indicates that, in this case, homochiral forms are more stable than racemate forms.

Probing the enantioselectivity of a diverse group of purified cobalt-centred nitrile hydratases

In this study a diverse range of purified cobalt containing nitrile hydratases (NHases, EC 4.2.1.84) from Rhodopseudomonas palustris HaA2 (HaA2), Rhodopseudomonas palustris CGA009 (009), Sinorhizobium meliloti 1021 (1021), and Nitriliruptor alkaliphilus (iso2), were screened for the first time for their enantioselectivity towards a broad range of chiral nitriles. Enantiomeric ratios of >100 were found for the NHases from HaA2 and CGA009 on 2-phenylpropionitrile. In contrast, the Fe-containing NHase from the well-characterized Rhodococcus erythropolis AJ270 (AJ270) was practically aselective with a range of different α-phenylacetonitriles. In general, at least one bulky group in close proximity to the α-position of the chiral nitriles seemed to be necessary for enantioselectivity with all NHases tested. Nitrile groups attached to a quaternary carbon atom were only reluctantly accepted and showed no selectivity. Enantiomeric ratios of 80 and >100 for AJ270 and iso2, respectively, were found for the pharmaceutical intermediate naproxennitrile, and 3-(1-cyanoethyl)benzoic acid was hydrated to the corresponding amide by iso2 with an enantiomeric ratio of >100.

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.