13375-29-6

Basic information

• Product Name: Dicyclopropane methylamine
• Synonyms: DICYCLOPROPYL METHYL AMINE;Dicyclopropane methylamine;AKOS MSC-0147;1,1-Dicyclopropane methylamine;1,1-dicyclopropylmethanamine 1;1,1-DICYCLOPROPYLMETHANAMINE HYDROCHLORIDE;a-cyclopropylcyclopropanemethanamine;α-Cyclopropylcyclopropanemethanamine
• CAS NO: 13375-29-6
• Molecular Formula: C₇H₁₃N
• Molecular Weight: 111.19
• EINECS: 236-451-7
• Product Categories: Pharmaceutical Intermediates
• Mol File: 13375-29-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 161.2 °C at 760 mmHg
• Flash Point: 45.7 °C
• Appearance: /
• Density: 1.092 g/cm³
• Vapor Pressure: 2.3mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.65±0.50(Predicted)
• CAS DataBase Reference: Dicyclopropane methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: Dicyclopropane methylamine(13375-29-6)
• EPA Substance Registry System: Dicyclopropane methylamine(13375-29-6)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 13375-29-6(Hazardous Substances Data)

Usage

Description

Dicyclopropane methylamine, also known as 1,1-dicyclopropylmethanamine, is an organic compound with the chemical formula C?H??N. It is a colorless liquid at room temperature and is used as a building block in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable intermediate in the development of new drugs.

Uses

Used in Pharmaceutical Industry:
Dicyclopropane methylamine is used as a reactant for the preparation of 4-dicyclopropylamino-7-aryl-7H-purines. These compounds serve as CRF-1 antagonists, which are important in the treatment of various stress-related disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD). The differentiated binding kinetic profiles of these antagonists allow for more targeted and effective treatment options.

InChI:InChI=1/C7H13N/c8-7(5-1-2-5)6-3-4-6/h5-7H,1-4,8H2

Upstream product

• 14300-33-5 dicyclopropylmethanol 
• 1121-37-5 dicyclopropyl ketone 
• 1453-52-7 dicyclopropylmethanone oxime 

Downstream Products

• 54187-43-8 dicyclopropylmethyl-carbamic acid phenyl ester 
• 1198109-37-3 dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine 
• 1198109-45-3 N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine 
• 1198109-32-8 C₂₁H₂₄ClN₅O 
• 1198108-98-3 dicyclopropylmethyl [9-(2-chloro-4-difluoromethoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine 
• 1198109-23-7 C₂₁H₂₂F₃N₅O 
• 1198109-04-4 C₂₂H₂₇N₅O 
• 1198109-29-3 C₂₀H₂₂FN₅ 
• 1198109-21-5 C₂₀H₂₂ClN₅ 
• 1339130-51-6 C₂₁H₂₅N₅O₂S 
• 1198109-08-8 C₂₁H₂₂N₆ 
• 1339130-50-5 C₂₄H₂₇F₂N₅O 
• 1339130-49-2 C₂₄H₂₉N₅O₂ 
• 1339130-48-1 C₂₄H₃₁N₅O 

Relevant articles and documents

Novel Carboxylic Acid and Carboxamide Protective Groups Based on the Exceptional Stabilization of the Cyclopropylmethyl Cation

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A process for the preparation of cyclopropyl methylamine

The invention relates to a method for preparing dicyclopropane methyl amine. The method comprises a step of performing catalytic hydrogenation on the dicyclopropane ketoxime and the hydrogen under the existence of a catalyst to generate the dicyclopropane methyl amine, wherein the raney nickel is taken as a catalyst in the catalytic hydrogenation and the process is performed in the water or the alkaline solution at the temperature of 30-90 DEG C. Compared with the current hydrogenation, the method has the advantages that a high-purity product with obviously increased yield can be obtained, the salt formation and dissociation process in an alcohol solvent can be avoided and the operation can be greatly simplified, besides, the costs of the solvent and the post-processing solvent can be greatly reduced, the wastewater discharge can be reduced and the process is green and environmentally friendly.

New imidazoline/α2-adrenoceptors affecting compounds-4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies

Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α2-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline and α2-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel 4(5)-(2-aminoethyl)imidazolines and their I 1, I2, α2-adrenoceptors affinities are reported.