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1335210-35-9

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  • (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide

    Cas No: 1335210-35-9

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  • Sinoway Industrial Co., Ltd.
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  • (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide

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  • NewblueCHEM (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide

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  • high purity (4R,12aS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12ahexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide

    Cas No: 1335210-35-9

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  • SAGECHEM/(4R,12aS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide

    Cas No: 1335210-35-9

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  • SAGECHEM LIMITED
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  • (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

    Cas No: 1335210-35-9

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  • Suzhou Health Chemicals Co., Ltd.
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1335210-35-9 Usage

Description

(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide, also known as Dolutegravir intermediate, is a new synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor used to treat human immunodeficiency virus (HIV)-1 infection.

Uses

Used in Pharmaceutical Industry:
(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide is used as an intermediate in the preparation of Dolutegravir, an integrase inhibitor for HIV-1 infection therapy. It plays a crucial role in the synthesis of Dolutegravir, which helps in the treatment of HIV-1 infection by inhibiting the integrase enzyme, thereby preventing the integration of the viral DNA into the host cell's genome.

Check Digit Verification of cas no

The CAS Registry Mumber 1335210-35-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,5,2,1 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1335210-35:
(9*1)+(8*3)+(7*3)+(6*5)+(5*2)+(4*1)+(3*0)+(2*3)+(1*5)=109
109 % 10 = 9
So 1335210-35-9 is a valid CAS Registry Number.

1335210-35-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

1.2 Other means of identification

Product number -
Other names (4R,12aS)-N-[[2,4-bis(fluoranyl)phenyl]methyl]-7-methoxy-4-methyl-6,8-bis(oxidanylidene)-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1335210-35-9 SDS

1335210-35-9Relevant articles and documents

Dolutegravir key intermediate solvate polymorph as well as preparation method and application thereof

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Paragraph 0086-0088, (2020/09/16)

The invention discloses a dolutegravir key intermediate solvate polymorph as well as a preparation method and application thereof. An X-ray powder diffraction (XRPD) pattern of the polymorph has characteristic peaks at the following angles of 2 theta +/-0.2 degrees: 6.93, 7.84, 8.42, 9.58, 11.14+/-0.2, 12.00, 13.15, 15.04, 15.31, 15.67, 16.20, 16.95, 17.54, 19.18, 19.97, 21.29, 21.82, 22.36, 23.55, 26.00 and 28.47, wherein n ranges from 0.2 to 1.

A kind of improved lu tewei preparation process (by machine translation)

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, (2019/02/13)

The present invention provides anti-aids drugs lu tewei improved preparation process, and for lu tewei bulk drug process control study of the diastereoisomeric synthetic intermediates 6' and its preparation method. The process for preparing the simple routes, simplified for intermediate purification processing, in addition this invention obtained the diastereoisomeric synthetic intermediates 6' help for lu tewei raw material preparation process of quality research. (by machine translation)

A new method for preparing lu Tewei (by machine translation)

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, (2017/08/28)

A process for preparing lu Tewei (E) new method, relates to the field of pharmaceutical chemistry, comprising the following steps: step 1) by the compound (A) with 2, 4 - two fluorine animal pen amine condensation reaction to obtain compound (B) steps 2) compound (B) removing the aldehyde protecting group to obtain the compound (C) step 3) compound (C) with R - 3 - amino - 1 - butanol on the ring by the reaction of the compound (D) step 4) compound (D) by the methylation reaction to occur after lu Tewei (E). This invention adopts the new line, and to the continuous optimization of the reaction conditions, so that the overall yield is raised greatly, as the compound (A) as a starting material and calculate the total yield is 75% or more, in a single reaction yield is 90% or more. (by machine translation)

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