1333492-69-5

Basic information

• Product Name: N,N-dimethyl-3-((4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,3'-bipyridin]-6'-yl)-oxy)propan-1-amine
• Synonyms: N,N-dimethyl-3-((4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,3'-bipyridin]-6'-yl)-oxy)propan-1-amine
• CAS NO: 1333492-69-5
• Molecular Weight: 642.803
• Mol File: 1333492-69-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-3-((4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,3'-bipyridin]-6'-yl)-oxy)propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-3-((4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,3'-bipyridin]-6'-yl)-oxy)propan-1-amine(1333492-69-5)
• EPA Substance Registry System: N,N-dimethyl-3-((4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,3'-bipyridin]-6'-yl)-oxy)propan-1-amine(1333492-69-5)

Safety Data

• Hazardous Substances Data: 1333492-69-5(Hazardous Substances Data)

Upstream product

• 2524-52-9 ethyl-2-picolinate 
• 4926-28-7 2-Bromo-4-picoline 
• 446880-83-7 2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine 
• 918643-56-8 N,N-dimethyl-3-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propane-1-amine 
• 446880-81-5 2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine 
• 446852-65-9 2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one 

Relevant articles and documents

2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling

Novel inhibitors of TGF-β1 and activin A signalling based on a 2-aryl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine pharmacophore have been synthesised. Compounds containing phenyl or aromatic nitrogen heterocycle substituents inhibited both types of signalling with HEK-293T cells in culture, with a selectivity preference for TGF-β1. Synthetic compounds containing pyridin-3-yl, pyrazol-4-yl, pyrazol-1-yl or 1H-imidazoyl-1-yl substituents exhibited structural and functional attributes suitable for further investigation related to the development of more potent TGF-β inhibitors.