133060-80-7

Basic information

• Product Name: 4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE
• Synonyms: ZD 7288;4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE;N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine;4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride;ZD7288 hydrate
• CAS NO: 133060-80-7
• Molecular Formula: C15H21ClN4
• Molecular Weight: 292.81
• Product Categories: Ion transporter and other ion channel
• Mol File: 133060-80-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 359.9±52.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.04±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear
• PKA: 11.97±0.70(Predicted)
• CAS DataBase Reference: 4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE(133060-80-7)
• EPA Substance Registry System: 4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE(133060-80-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 133060-80-7(Hazardous Substances Data)

Usage

Description

4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE is a chemical compound with the molecular formula C15H21ClN4. It is a derivative of pyrimidine, an important class of heterocyclic organic compounds with various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE is used as an Ih blocker for studying its effect on neocortical tissue. It plays a crucial role in understanding the underlying mechanisms of various neurological disorders and their treatment.
Used in Research Applications:
In the field of research, 4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE is used as a hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker. This application helps researchers investigate the involvement of HCN channels in the phototransduction pathway, which is essential for understanding the process of vision and related conditions.
Used in Chemical Synthesis:
4-ETHYLPHENYLAMINO-1,2-DIMETHYL-6-METHYLAMINOPYRIMIDINIUM CHLORIDE can also be used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting ion channels and receptors. Its unique chemical structure allows for further modification and functionalization, making it a valuable building block in the development of new drugs and therapeutic agents.

Biochem/physiol Actions

Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.

InChI:InChI=1/C15H20N4.ClH/c1-5-12-8-6-7-9-13(12)18-14-10-15(16-3)19(4)11(2)17-14;/h6-10H,5H2,1-4H3,(H,16,18);1H

Upstream product

• 133059-95-7 1,2-dimethyl-6-methylamino-4-N-ethylanilinopyrimidinium iodide 

Relevant articles and documents

Pyrimidine derivatives

This invention concerns novel aminopyrimidinium salts of the formula I: STR1 in which R1 is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl or cycloalkyl-alkyl; one of R2 and R6 is a basic group selected from amino, alkyla