132922-37-3 Usage
Description
2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide, also known as 3-(2-Methoxy-2-oxoethyl)indole, is a synthetic organic compound belonging to the class of N-alkylacetamides. It is a derivative of indole, a heterocyclic aromatic compound, with a methoxy and methyl group attached to the nitrogen atom. 2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide has been studied for its potential pharmacological activities, such as acting as a neuropeptide FF receptor antagonist and its potential use as a psychotropic drug. Due to its aromatic nature and potential biological activities, 2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide is of interest in medicinal chemistry for developing new drug candidates.
Uses
Used in Pharmaceutical Industry:
2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide is used as a research compound for its potential pharmacological activities. It is being studied for its role as a neuropeptide FF receptor antagonist, which could have implications in the development of treatments for pain management and addiction.
Used in Medicinal Chemistry:
2-(1H-indol-3-yl)-N-Methoxy-N-MethylacetaMide is used as a starting point for the development of new drug candidates. Its aromatic nature and potential biological activities make it a promising compound for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 132922-37-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,9,2 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 132922-37:
(8*1)+(7*3)+(6*2)+(5*9)+(4*2)+(3*2)+(2*3)+(1*7)=113
113 % 10 = 3
So 132922-37-3 is a valid CAS Registry Number.
132922-37-3Relevant articles and documents
A Thiol-Mediated Three-Step Ring Expansion Cascade for the Conversion of Indoles into Functionalized Quinolines
Inprung, Nantachai,James, Michael J.,Taylor, Richard J. K.,Unsworth, William P.
, p. 2063 - 2068 (2021)
An operationally simple, high yielding three-step cascade process is described for the direct conversion of indole-tethered ynones into functionalized quinolines. A single multitasking thiol reagent is used to promote a three-step dearomatizing spirocyclization, nucleophilic substitution, and one-atom ring expansion reaction cascade under remarkably mild conditions. In addition, a novel route to thio-oxindoles is described, which was discovered by serendipity.