1328893-16-8 Usage
Description
5-Bromo-1H-pyrazole-3-carboxylic acid is an organic compound with the molecular formula C5H3BrN2O2. It is a key intermediate in the synthesis of various biologically active molecules and has potential applications in the pharmaceutical industry due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
5-Bromo-1H-pyrazole-3-carboxylic acid is used as a key intermediate for the synthesis of novel inhibitors of Rho/MRTF/SRF transcription. These inhibitors have potential antifibrotic properties, making them valuable in the development of treatments for scleroderma, a chronic autoimmune disease characterized by the thickening and hardening of the skin and connective tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 1328893-16-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,2,8,8,9 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1328893-16:
(9*1)+(8*3)+(7*2)+(6*8)+(5*8)+(4*9)+(3*3)+(2*1)+(1*6)=188
188 % 10 = 8
So 1328893-16-8 is a valid CAS Registry Number.
1328893-16-8Relevant articles and documents
Method for synthesizing chlorantraniliprole
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Paragraph 0024; 0029; 0032; 0037; 0040; 0045, (2021/10/11)
A solvent containing 2 - amino -3 - methylbenzoic acid is stirred, N - methyl -3 - methyl -2 - amino - benzamide is dissolved in alkali liquor in a stirring reaction process, and reacted with NCS to obtain N - methyl -3 - methyl -2 - amino -5 - chloro - benzamide. The reaction of the bromination reaction, the oxidation reaction and the condensation reaction is carried out by cooperation of a catalyst so as to obtain chlorantraniliprole. By optimizing the preparation steps of chlorantraniliprole, the whole process is relatively simple in process steps, the post-treatment is simple, intermediate products can be obtained directly after the single step is finished, high environmental control requirements are not needed in the whole synthesis step, and industrialization can be conveniently realized.
