1313913-36-8Relevant articles and documents
Efficient three-step one-pot synthesis of a novel 2,3,5-substituted pyrazine library
Delvare, Christian,Harris, Craig S.,Hennequin, Laurent,Koza, Patrice,Lambert-Van Der Brempt, Christine,Pelleter, Jacques,Willerval, Olivier
, p. 449 - 452 (2011/11/29)
The partnership between rational synthesis design and mass-triggered preparative LCMS is a powerful one, capable of furnishing very large libraries in a selective manner in a very short space of time. Herein, we communicate one example of possibly a perfect marriage between the synthetic chemistry and the subsequent purification method employed, affording a ~1000-member library supplying 50 mg on average of final compound in less than a month.