1313725-88-0

Basic information

• Product Name: Volitinib
• Synonyms: AZD6094,Volitinib, HMPL-504, Savolitinib;1-[(1S)-1-Imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine;(S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine;Volitinib;Savolitinib;HMPL-504(AZD6094, Volitinib);EOS-60799;AZD-6094)
• CAS NO: 1313725-88-0
• Molecular Formula: C17H15N9
• Molecular Weight: 345.3613
• Product Categories: API
• Mol File: 1313725-88-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 5.67±0.50(Predicted)
• CAS DataBase Reference: Volitinib(CAS DataBase Reference)
• NIST Chemistry Reference: Volitinib(1313725-88-0)
• EPA Substance Registry System: Volitinib(1313725-88-0)

Safety Data

• Hazardous Substances Data: 1313725-88-0(Hazardous Substances Data)

Usage

Description

Volitinib, also known as Savolitinib, is a potent and highly selective c-Met inhibitor. It has demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models and has shown good anti-tumor activities.

Uses

Used in Oncology:
Volitinib is used as an anti-cancer agent for the treatment of cMet-dysregulated gastric cancer. It inhibits the c-Met receptor, which is often overactivated in various cancers, leading to the inhibition of tumor growth and progression.
Used in Drug Development:
Volitinib is used as a research compound for the development of new cancer therapies targeting the c-Met pathway. Its high selectivity and potent inhibitory activity make it a valuable tool for studying the role of c-Met in cancer and for developing new drugs to target this pathway.

Upstream product

• 1313723-58-8 1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 
• 1270475-03-0 1-(imidazo[1,2-a]pyridin-6-yl)ethanamine 
• 36052-24-1 methyl 6-aminonicotinoate 
• 136117-69-6 methyl 6-imidazo<1,2-a>pyridinecarboxylate 
• 1313726-20-3 imidazo[1,2-a]pyridine-6-carboxylic acid methoxy(methyl)amide 
• 944905-12-8 1-(imidazo[1,2-a]pyridin-6-yl)ethanone 
• 1259603-82-1 (1S)-1-imidazo[1,2-a]pyridin-6-ylethanamine 
• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 3167-49-5 6-aminonicotinic acid 
• 139022-25-6 imidazo[1,2-a]pyridine-6-carboxylic acid 

Relevant articles and documents

Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib

A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.

IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF

This specification generally relates to an improved method for the manufacture of 3-[(lS)-l -imidazo[ 1,2-a]pyridin-6-ylethyl]-5-(l-methylpyrazol-4-yl)triazolo[4,5- bjpyrazine (I), or pharmaceutically acceptable salts thereof; polymorphic forms thereof; and intermediates useful in the manufacture of such compounds and salts thereof. Formula (I).

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.