1313202-27-5Relevant articles and documents
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation
Chen, Jian Jeffrey,Nguyen, Thomas,D'Amico, Derin C.,Qian, Wenyuan,Human, Jason,Aya, Toshihiro,Biswas, Kaustav,Fotsch, Christopher,Han, Nianhe,Liu, Qingyian,Nishimura, Nobuko,Peterkin, Tanya A.N.,Yang, Kevin,Zhu, Jiawang,Riahi, Babak Bobby,Hungate, Randall W.,Andersen, Neil G.,Colyer, John T.,Faul, Margaret M.,Kamassah, Augustus,Wang, Judy,Jona, Janan,Kumar, Gondi,Johnson, Eileen,Askew, Benny C.
, p. 3384 - 3389 (2011/06/24)
The discovery of novel and highly potent oxopiperazine based B1 receptor antagonists is described. Compared to the previously described arylsulfonylated (R)-3-amino-3-phenylpropionic acid series, the current compounds showed improved in vitro potency and
