130973-54-5Relevant articles and documents
Chiral toluene-2,α-sultam auxiliaries: preparation and structure of enantiomerically pure (R)- and (S)-ethyl-2-1'-sultam
Oppolzer,Wills,Starkemann,Benardinelli
, p. 4117 - 4120 (1990)
Crystalline sultams (R)-2 or (S)-2 were selectively prepared from prochiral saccharine (3) in two steps (53% overall yield) via Ru-(R)-BINAP- or Ru-(S)-BINAP catalyzed asymmetric hydrogenation of imine 4. Alternatively, pure (R)-2 was synthesized (37%) overall yield) from (R)-α-phenethylamine in 4-5 steps involving the ortho-sulfination 6→7 and the highly diastereoselective cyclization of sulfinic acid 7 to the sulfinamide 8. X-ray diffraction analyses of sulfinamide 8 and sultam (R)-2 are presented.
Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
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Page/Page column 86, (2010/11/25)
The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
Recoverable Chiral Sulfoxides for Asymmetric Synthesis: Preparation, Regeneration and Application to the Asymmetric Aldol Reaction
Butlin, Roger J.,Linney, Ian D.,Critcher, Douglas J.,Mahon, Mary F.,Molloy, Kieran C.,Wills, Martin
, p. 1581 - 1590 (2007/10/02)
The synthesis of a novel source of chiral sulfoxide and its application to the control of asymmetric aldol reactions is described.The sulfoxide precursor S(S)R-(+)-cis-4 may be recycled and thus affords a considerable advantage over currently a