13095-73-3

Basic information

• Product Name: 4-MERCAPTOBUTYRIC ACID
• Synonyms: 4-mercapto-butanoicaci;4-mercapto-butyricaci;gamma-mercaptobutyricacid;4-MERCAPTOBUTYRIC ACID;4-Thiobutyric Acid;4-Mercaptobutyric Acid Tech Grade;4-Mercaptobutanoic Acid;Butanoic acid, 4-Mercapto-
• CAS NO: 13095-73-3
• Molecular Formula: C₄H₈O₂S
• Molecular Weight: 120.17
• EINECS: 236-013-5
• Product Categories: Metal Isotopes;Sulfur & Selenium Compounds
• Mol File: 13095-73-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 128-129°C @11mm
• Flash Point: 112.6°C
• Appearance: /
• Density: 1.164g/cm³
• Solubility: Chloroform
• PKA: 4.65±0.10(Predicted)
• CAS DataBase Reference: 4-MERCAPTOBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MERCAPTOBUTYRIC ACID(13095-73-3)
• EPA Substance Registry System: 4-MERCAPTOBUTYRIC ACID(13095-73-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• RIDADR: UN 3334
• WGK Germany: 3
• Hazardous Substances Data: 13095-73-3(Hazardous Substances Data)

Usage

Description

4-Mercaptobutyric Acid, also known as 4-MBA, is an organic compound characterized by the presence of a thiol (-SH) group and a carboxylic acid (-COOH) group. It is a colorless to pale yellow liquid with a strong, unpleasant odor. 4-MERCAPTOBUTYRIC ACID is known for its unique chemical properties, including its reactivity and ability to form complexes with various metal ions. These characteristics make 4-Mercaptobutyric Acid a versatile building block in chemical synthesis and a valuable intermediate in the production of various organic compounds.

Uses

Used in Chemical Synthesis:
4-Mercaptobutyric Acid is used as a synthetic intermediate for the production of a wide range of organic compounds. Its reactivity and functional groups make it a useful building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Acyclic Compounds:
4-Mercaptobutyric Acid is used as a precursor in the synthesis of acyclic compounds, which are characterized by their open chain structure. These compounds have various applications in different industries, including the production of solvents, detergents, and other industrial chemicals.
Used in Alkanes:
4-Mercaptobutyric Acid can be used in the synthesis of alkanes, which are saturated hydrocarbons with single bonds between carbon atoms. Alkanes are widely used as fuels, solvents, and raw materials for the production of various chemical products.
Used in Building Blocks:
As an organic building block, 4-Mercaptobutyric Acid is employed in the construction of more complex organic molecules. Its presence in these molecules can impart unique properties, such as increased reactivity or the ability to form stable complexes with metal ions.
Used in the Production of Thiols:
4-Mercaptobutyric Acid can be used as a starting material for the synthesis of other thiols, which are important in various applications, including the production of rubber, pharmaceuticals, and agrochemicals. Thiols are known for their strong, characteristic odor and their ability to react with a wide range of compounds.

InChI:InChI=1/C4H8O2S/c5-4(6)2-1-3-7/h7H,1-3H2,(H,5,6)

Upstream product

• 96-48-0 4-butanolide 
• 17356-08-0 thiourea 
• 70124-54-8 ethyl 4-mercaptobutanoate 
• 1003-10-7 Thiobutyrolactone 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 2623-87-2 bromobutyric acid 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 2906-60-7 5,6-dithia-decanedioic acid 
• 101421-82-3 S-acetyl-4-mercaptobutyric acid 

Downstream Products

• 1003-10-7 Thiobutyrolactone 
• 377733-71-6 4-[(triphenylmethyl)thio]butanoic acid 
• 32391-97-2 4-(methylthio)butanoic acid 
• 2906-60-7 5,6-dithia-decanedioic acid 
• 1160162-67-3 (RS)-2-amino-4-[(3-carboxypropyl)disulfanyl]butanoic acid 
• 107-92-6 butyric acid 
• 250266-79-6 4-(pyridin-2-yldisulfanyl)butanoic acid 

Relevant articles and documents

A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease

A self-assembled and oxidation-degradable Janus-prodrug, termed as Bud-ATK-Tem (B-ATK-T), was fabricated by ROS-responsive aromatized thioketal (ATK) linked anti-inflammatory drug budesonide (Bud) and antioxidant tempol (Tem). Benefiting from the hydrophobic interactions and π-π stacking interactions of ATK, prodrug B-ATK-T could self-assemble into nanoparticles (NP) in water containing lecithin and DSPE-PEG2K. The morphology of B-ATK-T NP (approximate 100–120 nm) was confirmed to be regular spherical by transmission electron microscope. B-ATK-T NP was endowed high drug loading content with 41.23% for Bud and 15.55% for Tem. The rapid drug release from B-ATK-T NP proceeded in an extensive reactive oxygen species (ROS)-dependent manner. More than 98% of Bud and Tem in B-ATK-T NP could release in the mimic inflammation microenvironment or phorbol-12-myristate-13-acetate (PMA)-stimulated macrophages within short time. The release of drugs in a simultaneous and proportional manner ensures that B-ATK-T NP can increase the combined efficacy of anti-inflammation and anti-oxidation. It is worth noting that B-ATK-T NP could be passively accumulated and dramatically increasing the maximum drugs concentration in the inflamed colon of mice with inflammatory bowel disease (IBD) by oral route, and avoiding potential systemic side effects. B-ATK-T NP could not only relieve colitis via inhibiting the expression of oxidative and proinflammatory mediators more than combination of free drugs, but also significantly reduce colitis-caused death. Taken together, the self-assembled, Janus-prodrug B-ATK-T NP is a promising candidate therapies for IBD, even for other inflammatory diseases.

Her2 targeted polypeptide drug conjugate as well as a preparation method and application thereof

The invention relates to an Her2 targeted polypeptide drug conjugate as well as a preparation method and application thereof. The Her2 targeted polypeptide drug conjugate has a molecular structural formula shown in a formula I, wherein Aaa1 is L or D type Lys or Arg; Aaa2 is L or D type Lys or Arg; X is CH2, NH or O; ROH is a hydrophobic antitumor drug; and n is 1 or 2. The Her2 targeted polypeptide drug conjugate provided by the invention can realize targeted drug delivery, the targeted polypeptide can transport the antitumor drug to specific tumor cells, the drug enters the tumor cells and then exerts the characteristic of specific degradation of disulfide bonds at tumor sites, and the antitumor drug is rapidly released. Compared with conventional joint arms such as 2,2'-dithiodiglycolicacid and 3,3'-dithiodipropionic acid, the Her2 targeted polypeptide drug conjugate provided by the invention has the advantages that an anticancer drug in the form of an original drug molecule can beobtained without further hydrolysis, the drug efficacy is improved, and the toxic and side effects on normal cells are reduced.

Based on molecular glue of the fluorescence-labeled nucleotide and its use in DNA sequencing

The invention discloses a fluorescence labelled nucleotide based on a molecular glue and a use thereof in DNA sequencing. The structure formula of the fluorescence labelled nucleotide is shown in a formula (I) in the specification, wherein R1 is shown in the specification, R2 is fluorescein or shown in the specification, and dNTP is ribonucleoside triphosphote which contains four different base groups; the fluorescein is selected from one of the BODIPY, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, a squarene dye, a composition for generating energy transfer dye and the derivatives thereof. The fluorescence labelled nucleotide can be used for DNA sequencing; simultaneously the raw materials for synthesizing the fluorescence labelled nucleotide are simple and easy to obtain and the fluorescence labelled nucleotide can be used for large-scale popularization. The biological assessment result shows that all the requirements of the high-throughput sequencing biochemical reaction can be satisfied by the reversible terminal, and the reversible terminal has good practical prospect.