1309357-47-8Relevant articles and documents
Cis-nitenpyram analogues containing 1,4-dihydropyridine: Synthesis, insecticidal activities, and molecular docking studies
Sun, Chuanwen,Chen, Yanxia,Liu, Tianyan,Wu, Ying,Fang, Ting,Wang, Jing,Xing, Jiahua
experimental part, p. 1415 - 1422 (2012/09/07)
A novel series of cis-nitenpyram analogues (2a-2p) were designed and prepared by introducing the 1,4-dihydropyridine, with their cis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most compounds exhibited good insecticidal activities at 20 mg/L against Aphis medicagini, and analogues 2a and 2d afforded the best activity, and both of them had 100% mortality at 4 mg/L. In addition, molecular docking studies were also performed to model the ligand-receptor complexes, and the results explained the structure-activity relationships observed in vitro, which may provide some useful information for future design of new insecticides. Copyright