1304723-91-8Relevant articles and documents
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
Xu, Rui,Banka, Anna,Blake, James F.,Mitchell, Ian S.,Wallace, Eli M.,Bencsik, Josef R.,Kallan, Nicholas C.,Spencer, Keith L.,Gloor, Susan L.,Martinson, Matthew,Risom, Tyler,Gross, Stefan D.,Morales, Tony H.,Wu, Wen-I,Vigers, Guy P.A.,Brandhuber, Barbara J.,Skelton, Nicholas J.
, p. 2335 - 2340 (2011/05/15)
We describe the design and synthesis of novel bicyclic spiro sulfonamides as potent Akt inhibitors. Through structure-based rational design, we have successfully improved PKA selectivity of previously disclosed spirochromanes. Representative compounds sho
