127915-15-5

Basic information

• Product Name: 2-oxotetrahydrofuran-3-carboxylic acid methyl ester
• Synonyms: 2-oxotetrahydrofuran-3-carboxylic acid methyl ester
• CAS NO: 127915-15-5
• Molecular Weight: 144.127
• Mol File: 127915-15-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-oxotetrahydrofuran-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxotetrahydrofuran-3-carboxylic acid methyl ester(127915-15-5)
• EPA Substance Registry System: 2-oxotetrahydrofuran-3-carboxylic acid methyl ester(127915-15-5)

Safety Data

• Hazardous Substances Data: 127915-15-5(Hazardous Substances Data)

Usage

Description

2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is a stable organic compound derived from tetrahydrofuran, a colorless liquid commonly used as a solvent. It is characterized by its potential therapeutic effects and versatility in organic synthesis, making it a valuable precursor in the synthesis of other organic compounds.

Uses

Used in Pharmaceutical Research and Drug Development:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is used as a precursor in pharmaceutical research and drug development for its potential therapeutic effects. It can be modified to create new drugs, contributing to the discovery and development of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-oxotetrahydrofuran-3-carboxylic acid methyl ester is used as a building block for the synthesis of various organic compounds. Its versatility allows for the creation of a wide range of chemical products.
Used in Specialty Chemicals Production:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is utilized in the production of specialty chemicals, where its unique properties contribute to the development of high-value chemical products.
Used in Flavor and Fragrance Industry:
2-oxotetrahydrofuran-3-carboxylic acid methyl ester also finds applications in the flavor and fragrance industry, where it is used to create unique scents and tastes for various consumer products.
Used in Other Industrial Products:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is employed in various other industrial applications, showcasing its diverse uses and the importance of this chemical compound in multiple sectors.

Upstream product

• 96-48-0 4-butanolide 
• 616-38-6 carbonic acid dimethyl ester 
• 4525-33-1 dimethyl dicarbonate 
• 107-31-3 Methyl formate 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 108-59-8 malonic acid dimethyl ester 
• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 

Downstream Products

• 547-65-9 α-methylene-γ-butyrolactone 
• 933770-71-9 α-benzyloxymethyl-γ-lactone 
• 89941-77-5 2-methoxy-tetrahydro-furan-3-carboxylic acid methyl ester 
• 1178564-19-6 1-[4-[2-[bis[(4-methoxyphenyl)methyl]amino]pyrimidin-5-yl]-2-morpholino-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]ethanone 
• 1007215-41-9 4-[4-chloro-7-[(4-methoxyphenyl)methyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine 
• 1007215-39-5 6-chloro-5-(2-chloroethyl)-N-[(4-methoxyphenyl)methyl]-2-morpholinopyrimidin-4-amine 
• 1007208-62-9 [3-[4-(2-aminopyrimidin-5-yl)-2-morpholino-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-(4-methylpiperazin-1-yl)methanone 
• 1007207-65-9 N,N-bis[(4-methoxyphenyl)methyl]-5-(2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine 
• 1007208-67-4 5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine 
• 1007210-13-0 [4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone 
• 1007208-40-3 [4-[4-(2-aminopyrimidin-5-yl)-2-morpholino-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

-Alkoxystannyl ethers in organic synthesis: Synthesis of functionalised γ-butyrolactones

Ozonolysis of a variety of (tetraydrofuran-2-yl)tri-n-butylstannanes affords the corresponding γ-butyrolactones in good to excellent yields. This reaction is tolerant to a range of other functional groups and provides access to substituted γ-butyrolactone

Enantioselective phase-transfer catalytic α-benzylation and α-allylation of α-tert-butoxycarbonyllactones

A new enantioselective α-benzylation and α-allylation of α-tert-butoxycarbonyllactones was devloped. α-Benzylation and α-allylation of α-tert-butoxycarbonylbutyrolactone and α-tert-butoxycarbonylvalerolactone under phase-transfer catalytic conditions (50% cesium hydroxide, toluene, -60 °C) in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide (1 mol%) afforded the corresponding α-substituted α-tert-butoxycarbonyllactones in very high chemical yields (up to 99%) and optical yields (up to 99% ee). The synthetic potential of this method has been successfully demonstrated by the asymmetric synthesis of unnatural α-quaternary homoserines, 3-alkyl-3-carboxypyrrolidine and 3-alkyl-3-carboxypiperidine. Copyright

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation

Our lead compound for a phosphoinositide 3-kinase (PI3K) inhibitor (1) was metabolically unstable because of rapid glucuronidation of the phenol moiety. Based on structure-activity relationship (SAR) information and a FlexSIS docking simulation score, aminopyrimidine was identified as a bioisostere of phenol. An X-ray structure study revealed a hydrogen bonding pattern of aminopyrimidine derivatives. Finally, aminopyrimidine derivatives 33 showed strong tumor growth inhibition against a KPL-4 breast cancer xenograft model in vivo.