126799-84-6

Basic information

• Product Name: Benzene, 1-(azidomethyl)-3-nitro-
• CAS NO: 126799-84-6
• Molecular Formula: C7H6N4O2
• Molecular Weight: 178.15
• Mol File: 126799-84-6.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(azidomethyl)-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(azidomethyl)-3-nitro-(126799-84-6)
• EPA Substance Registry System: Benzene, 1-(azidomethyl)-3-nitro-(126799-84-6)

Safety Data

• Hazardous Substances Data: 126799-84-6(Hazardous Substances Data)

Upstream product

• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 99-61-6 3-nitro-benzaldehyde 
• 121-92-6 3-nitrobenzoic acid 
• 619-23-8 3-Nitrobenzyl chloride 
• 99-08-1 1-methyl-3-nitrobenzene 
• 619-25-0 3-Nitrobenzyl alcohol 

Downstream Products

• 141072-11-9 methyl 1-(3-nitrobenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 141071-98-9 di-tert-butyl 1-(3-nitrobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 126799-92-6 dimethyl 1-(3-nitrobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 126800-29-1 ethyl 1-(3-nitrobenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 4403-70-7 m-aminobenzylamine 
• 7409-18-9 3-nitrobenzylamine 
• 99-61-6 3-nitro-benzaldehyde 
• 1295479-68-3 C₂₅H₂₈F₂N₈O₃ 
• 1374585-80-4 [1-(3-nitro-benzyl)-1H-[1,2,3]triazol-4-yI]-methanol 
• 1374585-81-5 [1-(3-amino-benzyl)-1H-[1,2,3]triazol-4-yl]-methanol 
• 1421036-21-6 1-(3-nitrobenzyl)-4-(trimethylsilyl)-1H-1,2,3-triazole 
• 63777-55-9 1-(3-nitrobenzyl)-1H-1,2,3-triazole 
• 1421036-28-3 1-(3,5-dinitrobenzyl)-1H-1,2,3-triazole 
• 1421036-29-4 1-(3,4-dinitrobenzyl)-1H-1,2,3-triazole 

Relevant articles and documents

A Photoregulated Racemase Mimic

The racemase enzymes convert L-amino acids to their D-isomer. The reaction proceeds through a stepwise deprotonation–reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP–photoswitch–imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.

Design, synthesis, and evaluation of metronidazole-1,2,3-triazole derivatives as potent urease inhibitors

A new series of metronidazole-1,2,3-triazole derivatives 6a–o was synthesized and evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were more potent than standard inhibitor thiourea against urease. Among the synthesized compounds, compound 6f (IC50 = 1.975 ± 0.25?μM) with inhibitory activity around 11-fols more than thiourea (IC50 = 22.00 ± 0.14?μM) was the most potent compound. Kinetic study of this compound revealed that compound 6f inhibited urease in an uncompetitive mode. Based on molecular modeling study, compound 6f pointed toward the bi-nickel center and stabilized by H-bond and T-shape π–π hydrophobic interactions with the critical residues His492 and Asp633. Moreover, it anchored to the helix-turn-helix motif in the active site cavity through interaction with His593 and Arg609. Consequently, it proposed that compound 6f through stabilization of active site flap inhibited urease activity.

Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies

The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1) (HCTZ, a diuretic drug also being used for the treatment of high blood pressure) was synt