1263039-73-1

Basic information

• Product Name: 4-methyl-2-(piperidin-1-ylmethyleneamino)phenol
• Synonyms: 4-methyl-2-(piperidin-1-ylmethyleneamino)phenol
• CAS NO: 1263039-73-1
• Molecular Weight: 218.299
• Mol File: 1263039-73-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-methyl-2-(piperidin-1-ylmethyleneamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-(piperidin-1-ylmethyleneamino)phenol(1263039-73-1)
• EPA Substance Registry System: 4-methyl-2-(piperidin-1-ylmethyleneamino)phenol(1263039-73-1)

Safety Data

• Hazardous Substances Data: 1263039-73-1(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 10531-78-9 5-methyl-1,3-benzoxazole 
• 95-84-1 3-amino-4-hydroxytoluene 

Downstream Products

• 10531-78-9 5-methyl-1,3-benzoxazole 
• 1263039-65-1 5-methyl-2-(piperidin-1-yl)benzo[d]oxazole 

Relevant articles and documents

Metal-free synthesis of 2-aminobenzoxazoles using hypervalent iodine reagent

A facile, simple, mild, and metal-free protocol for the synthesis of 2-aminobenzoxazoles has been developed via C-H bond amination of benzoxazoles with amines through a ring-opening and subsequent ring-closure approach. The reaction was performed in two steps wherein nucleophilic addition of amines across benzoxazoles takes place in the absence of any reagent or catalyst under solvent-free condition, followed by oxidative ring closure using 2-iodoxybenzoic acid as a hypervalent iodine reagent. Various cyclic, acyclic, and functionalized aliphatic amines were well tolerated under optimized reaction conditions and provided good to excellent yield of respective 2-aminobenzoxazoles.

Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6- tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant

No transition metals are necessary to convert benzoxazoles and 1,3,4-oxadiazoles into the corresponding pharmacologically interesting 2-aminated heterocycles by formal direct C(2)-amination using tetramethylpiperidine-N-oxoammonium tetrafluoroborate (TEMPO+BF 4-) as an oxidant (see scheme; TEMP=2,2,6,6- tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

Cobalt- and manganese-catalyzed direct amination of azoles under mild reaction conditions and the mechanistic details

A bonding moment: A new cobalt- or manganese-catalyzed amination of azoles has been developed using peroxide and an acid additive to couple various types of azoles with ammonia, and primary or secondary amines (see scheme). The catalyst loadings are low, the optimal reaction conditions are mild, and the substrate scope is broad. The product azoles are an important pharmacophore of high biological activity. Copyright