1258391-78-4Relevant articles and documents
Total synthesis of the marine antibiotic pestalone and its surprisingly facile conversion into pestalalactone and pestalachloride A
Slavov, Nikolay,Cvengros, Jan,Neudoerfl, Joerg-Martin,Schmalz, Hans-Guenther
supporting information; experimental part, p. 7588 - 7591 (2010/12/25)
Surprise, surprise! The total synthesis of the marine natural product pestalone (1), a highly substituted benzophenone with strong antibiotic acitivity, has provided insight into the surprising tendency of this and related molecules to undergo intramolecular Cannizzaro-Tishchenko-type reactions. Pestalone can be readily converted into pestalachloride A, a strongly antifungal metabolite isolated from an endophytic fungus, by simple treatment with ammonia at pH 8.