125574-10-9

Basic information

• Product Name: 3',4'-benzo-2',4-dihydroxychalcone
• Synonyms: 3',4'-benzo-2',4-dihydroxychalcone
• CAS NO: 125574-10-9
• Molecular Weight: 290.318
• Mol File: 125574-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',4'-benzo-2',4-dihydroxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-benzo-2',4-dihydroxychalcone(125574-10-9)
• EPA Substance Registry System: 3',4'-benzo-2',4-dihydroxychalcone(125574-10-9)

Safety Data

• Hazardous Substances Data: 125574-10-9(Hazardous Substances Data)

Upstream product

• 711-79-5 1-hydroxy-2-acetonaphthone 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 110973-41-6 2-(4-hydroxy-phenyl)-2,3-dihydro-benzo[h]chromen-4-one 

Relevant articles and documents

New 7,8-benzoflavanones as potent aromatase inhibitors: Synthesis and biological evaluation

Some natural compounds such as flavonoids are known to possess a moderate inhibitory activity against aromatase, this enzyme being an interesting target for hormone-dependent breast cancer treatment. It has been demonstrated that the modulation of flavonoid skeleton could increase anti-aromatase effect. Therefore, new 7,8-benzoflavanones were synthesized and tested for their activity toward aromatase inhibition. It was observed that the introduction of a benzo ring at position C-7 and C-8 on flavanone skeleton led to new potent aromatase inhibitors, the resulting 7,8-benzoflavanones being until nine times more potent than aminogluthetimide (the first aromatase inhibitor used clinically).