125-04-2 Usage
Description
Hydrocortisone sodium succinate, also known as Hydrocortisone Hemisuccinate Sodium, is a water-soluble derivative of the glucocorticoid Hydrocortisone (H714615). It is a pharmaceutical compound that exhibits anti-inflammatory and immunosuppressive properties by binding to glucocorticoid receptors and initiating the transcription of relevant mediators. Hydrocortisone sodium succinate is also used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.
Uses
Used in Pharmaceutical Industry:
Hydrocortisone sodium succinate is used as an anti-inflammatory agent for the treatment of various conditions, including asthma, endocrine disorders, dermatological disorders, and allergic states. It helps in managing inflammation and immune responses in the body.
Used in Cell Culture Applications:
Hydrocortisone sodium succinate is used as a supplement in media for long-term epithelial or endothelial adherent cell cultures. It aids in maintaining the health and functionality of these cells during extended periods of cultivation.
Used in Stem Cell Differentiation:
Hydrocortisone sodium succinate is used to differentiate pluripotent stem cells, which is crucial for various regenerative medicine and therapeutic applications.
Brand names for Hydrocortisone sodium succinate include A-Hydrocort (Abbott), A-Hydrocort (Hospira), and Solu-Cortef (Pharmacia & Upjohn).
Clinical Use
#N/A
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines.
Metabolism
Hydrocortisone is metabolised in the liver and most
body tissues to hydrogenated and degraded forms such as
tetrahydrocortisone and tetrahydrocortisol.
These are excreted in the urine, mainly conjugated as
glucuronides, with a very small proportion of unchanged
hydrocortisone.
Check Digit Verification of cas no
The CAS Registry Mumber 125-04-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 125-04:
(5*1)+(4*2)+(3*5)+(2*0)+(1*4)=32
32 % 10 = 2
So 125-04-2 is a valid CAS Registry Number.
InChI:InChI=1/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1