1234-35-1 Usage
Description
Nalpha-Cbz-L-Arginine, also known as Carbobenzyloxy-L-arginine, is a synthetic derivative of the naturally occurring amino acid L-arginine. It is characterized by the presence of a carbobenzyloxy (Cbz) protecting group attached to the alpha-amino group, which plays a crucial role in its chemical properties and applications. Nalpha-Cbz-L-Arginine is a white powder and is commonly used in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
Nalpha-Cbz-L-Arginine is used as an intermediate in the synthesis of renin inhibitors containing phosphorous acid derivatives at the scissile bond. These renin inhibitors are important for the development of drugs targeting hypertension and other cardiovascular diseases, as they help regulate the renin-angiotensin-aldosterone system.
Used in Peptide Synthesis:
Nalpha-Cbz-L-Arginine is used as a building block in the synthesis of peptides, particularly in the development of peptide deformylase inhibitors such as BB-3497. Peptide deformylase inhibitors are of interest in the field of antibiotic research, as they have the potential to target bacterial protein synthesis and combat drug-resistant infections.
Used in Chemical Research:
Nalpha-Cbz-L-Arginine is also used in chemical research for the study of its unique chemical properties, such as its reactivity and stability. The presence of the carbobenzyloxy protecting group allows for controlled reactions and selective modifications, making it a valuable compound for exploring new chemical reactions and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1234-35-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,3 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1234-35:
(6*1)+(5*2)+(4*3)+(3*4)+(2*3)+(1*5)=51
51 % 10 = 1
So 1234-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H20N4O4/c15-13(16)17-8-4-7-11(12(19)20)18-14(21)22-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,18,21)(H,19,20)(H4,15,16,17)/t11-/m0/s1
1234-35-1Relevant articles and documents
NaBH4 - A novel method for the deprotection of Nω-nitro-arginine
Sebestyén, Mónika,Kóczán, Gy?rgy,Csámpai, Antal,Hudecz, Ferenc
, p. 546 - 548 (2016)
The selective deprotection of Nω-nitro-arginine derivatives represents a major preparative challenge. This problem can be circumvented by the use of catalytic hydrogenation, but often high pressure, elevated temperature, and/or long reaction times are needed. In certain cases hydrogenation is not suitable, for example, small-scale reactions, parallel synthesis, or due to selectivity issues. Herein, we demonstrate for the first time, the use of NaBH4 in the presence of a metal ion catalyst for the removal of the Nω-nitro moiety under simple, 'open-vessel' conditions. This process using NaBH4 does not remove the benzyloxycarbonyl-protecting group; thus the method is orthogonal for this protecting scheme.
Direct guanylation of amino groups by cyanamide in water: Catalytic generation and activation of unsubstituted carbodiimide by scandium(iii) triflate
Tsubokura, Kazuki,Iwata, Takayuki,Taichi, Misako,Kurbangalieva, Almira,Fukase, Koichi,Nakao, Yoichi,Tanaka, Katsunori
, p. 1302 - 1306 (2014/06/10)
Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds. Georg Thieme Verlag Stuttgart New York.
The total large-scale synthesis of argiopine
Formanovsky,Popova,Mikhura
experimental part, p. 752 - 758 (2010/07/15)
The total large-scale synthesis of a natural toxin argiopine, a polymethylenepolyamine derivative, was developed. It consisted of 26 stages and included three key block schemes. Most of the stages proceeded quantitatively, which excluded the necessity of using the chromatographic separation of intermediates.