1227781-92-1Relevant articles and documents
Palladium-catalyzed ionic liquid-accelerated oxidative annulation of acetylenic oximes with unactivated long-chain enols
Hu, Miao,Jiang, Huanfeng,Li, Jianxiao,Lin, Zidong,Wu, Wanqing
, p. 5584 - 5588 (2020)
A palladium-catalyzed ionic liquid-accelerated oxidative cascade annulation/functionalization of acetylenic oximes with unactivated long-chain enols under aerobic conditions was accomplished. This newly developed protocol provides the rapid and straightforward synthetic strategy for the assembly of structurally diverse isoxazole architectures under mild conditions with high atom- and step-economy and exceptional functional group tolerance. Notably, the ionic liquid acts as not only a solvent in the reaction but also provides the excess halide ions to eliminate hydrochloride from acetylenic oximes. Moreover, this catalytic system could be recycled up to eight times and reused without significant loss of the catalytic activity.
Synthesis method of 4-allyl-3,5-disubstituted isooxazole
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Paragraph 0051; 0052; 0053; 0059, (2018/12/13)
The invention discloses a synthesis method of 4-allyl-3,5-disubstituted isooxazole, and belongs to the technical field of organic synthesis. The synthesis method is characterized in that in a reactor,acetyenic ketone oxime ether substrates, 3-bromopropyle