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1220286-46-3

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1220286-46-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1220286-46-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,0,2,8 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1220286-46:
(9*1)+(8*2)+(7*2)+(6*0)+(5*2)+(4*8)+(3*6)+(2*4)+(1*6)=113
113 % 10 = 3
So 1220286-46-3 is a valid CAS Registry Number.

1220286-46-3Downstream Products

1220286-46-3Relevant articles and documents

Nitromethylene neonicotinoids analogues with tetrahydropyrimidine fixed cis-configuration: Synthesis, lnsecticidal activities, and molecular docking studies

Chuanwen, Sun,Dingrong, Yang,Jiahua, Xing,Haifeng, Wang,Jia, Jin,Jun, Zhu

, p. 3415 - 3421 (2011/07/30)

Two series of new nitromethylene neonicotinoid analogues (2a-2h and 3a-3h) were designed and prepared, with the cis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most analogues exhibited excellent insectlcidal activities at 500 mg/L, and analogues with optical activity (2c-2g) were highly potent at 100 mg/L, while compound 2d had >90% mortality at 20 mg/L, which suggested that it could be used as a lead for future insecticides development. Modeling the ligand-receptor complexes by molecular docking study explained the structureactivity relationships observed in vitro and revealed an intriguing molecular binding mode at the active site of the nAChR model, thereby possibly providing some useful information for future receptor structure-based designs of novel insecticidal compounds.

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