1218778-29-0Relevant articles and documents
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone
Mollica, Adriano,Stefanucci, Azzurra,Feliciani, Federica,Torino, Domenica,Cacciatore, Ivana,Pinnen, Francesco,Lucente, Gino
, p. 1333 - 1335 (2010)
In this Letter we present a simple reaction pathway which allows the conversion of the glutamic acid residue of a tripeptide into a proline residue. The reaction was performed by using Boc-Val-Glu-Phe-NH2 as a starting material and is based on a NaH-induced intraresidue alkylation under reaction conditions analogous to that adopted during the Freidinger lactams formation.