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1208534-92-2

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1208534-92-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1208534-92-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,5,3 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1208534-92:
(9*1)+(8*2)+(7*0)+(6*8)+(5*5)+(4*3)+(3*4)+(2*9)+(1*2)=142
142 % 10 = 2
So 1208534-92-2 is a valid CAS Registry Number.

1208534-92-2Downstream Products

1208534-92-2Relevant articles and documents

Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease

Khan, Khalid Mohammed,Rahim, Fazal,Khan, Ajmal,Shabeer, Muhammad,Hussain, Shafqat,Rehman, Wajid,Taha, Muhammad,Khan, Momin,Perveen, Shahnaz,Choudhary, M. Iqbal

, p. 4119 - 4123 (2014/08/18)

A series of thiobarbituric acid derivatives 1-27 were synthesized and evaluated for their urease inhibitory potential. Exciting results were obtained from the screening of these compounds 1-27. Compounds 5, 7, 8, 11, 16, 17, 22, 23 and 24 showed excellent urease inhibition with IC50 values 18.1 ± 0.52, 16.0 ± 0.45, 16.0 ± 0.22, 14.3 ± 0.27, 6.7 ± 0.27, 10.6 ± 0.17, 19.2 ± 0.29, 18.2 ± 0.76 and 1.61 ± 0.18 μM, respectively, much better than the standard urease inhibitor thiourea (IC50 = 21 ± 0.11 μM). Compound 3, 4, 10, and 26 exhibited comparable activities to the standard with IC50 values 21.4 ± 1.04 and 21.5 ± 0.61μM, 22.8 ± 0.32, 25.2 ± 0.63, respectively. However the remaining compounds also showed prominent inhibitory potential The structure-activity relationship was established for these compounds. This study identified a novel class of urease inhibitors. The structures of all compounds were confirmed through spectroscopic techniques such as EI-MS and 1H NMR.

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