1206-37-7

Basic information

• Product Name: 4-DIMETHYLSULFAMOYL-BENZOIC ACID
• Synonyms: benzoic acid, 4-[(dimethylamino)sulfonyl]-;4-(N,N-DiMethylsulfaMoyl)benzoic acid;BENZOIC ACID, p-(DIMETHYLSULFAMOYL)-
• CAS NO: 1206-37-7
• Molecular Formula: C₉H₁₁NO₄S
• Molecular Weight: 229.26
• Mol File: 1206-37-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 397.3 °C at 760 mmHg
• Flash Point: 194.1 °C
• Appearance: /
• Density: 1.368 g/cm³
• Vapor Pressure: 5.02E-07mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-DIMETHYLSULFAMOYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYLSULFAMOYL-BENZOIC ACID(1206-37-7)
• EPA Substance Registry System: 4-DIMETHYLSULFAMOYL-BENZOIC ACID(1206-37-7)

Safety Data

• Hazardous Substances Data: 1206-37-7(Hazardous Substances Data)

Usage

General Description

4-Dimethylsulfamoyl-benzoic Acid is an organic chemical compound with its molecular formula being C9H11NO4S. As the name indicates, it is a derivative of benzoic acid and contains a sulfamoyl functional group where sulfur atom is bound to two oxygen atoms. It is usually a white crystalline solid at room temperature. It is not naturally occurring and has to be synthesized in a lab for various industrial or scientific purposes such as serving as an intermediate compound for the synthesis of pharmaceuticals, dyes, or other organic compounds. As it's a chemical compound, precautions should be taken while handling to avoid direct exposure, ingestion, or inhalation that could potentially be harmful.

InChI:InChI=1/C9H11NO4S/c1-10(2)15(13,14)8-5-3-7(4-6-8)9(11)12/h3-6H,1-2H3,(H,11,12)

Upstream product

• 63877-94-1 4-cyano-N,N-dimethylbenzenesulfonamide 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 124-40-3 dimethyl amine 
• 10486-51-8 4-ethoxycarbonylbenzenesulfonyl chloride 
• 138-41-0 4-(aminosulfonyl)-benzoic acid 
• 77-78-1 dimethyl sulfate 
• 599-69-9 N,N,4-trimethylbenzenesulfonamide 
• 83112-37-2 4-<(Dimethylamino)sulfonyl>benzoic Acid Ethyl Ester 

Downstream Products

• 58804-18-5 4-hydroxymethyl-benzenesulfonic acid dimethylamide 
• 96134-56-4 N,N-Dimethyl-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-benzenesulfonamide 
• 96134-55-3 4-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-N,N-dimethyl-benzenesulfonamide 
• 96134-54-2 4-(5-Methyl-1,3,4-oxadiazol-2-yl)-N,N-dimethylbenzenesulfonamide 
• 96134-53-1 N,N-Dimethyl-4-[1,3,4]oxadiazol-2-yl-benzenesulfonamide 
• 53554-96-4 4-<(Dimethylamino)sulfonyl>benzoic Acid Hydrazide 
• 83112-37-2 4-<(Dimethylamino)sulfonyl>benzoic Acid Ethyl Ester 
• 857486-81-8 4-dimethylsulfamoyl-benzoic acid methylamide 
• 29171-70-8 4-(N,N-dimethylaminosulfonyl)benzoyl chloride 

Relevant articles and documents

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.

NOVEL QUINOLINE ESTERS USEFUL FOR TREATING SKIN DISORDERS

Disclosed are quinoline esters of Formula (I): which are useful as Liver X receptors (LXR) modulators. Pharmaceutical compositions containing quinoline esters of Formula (I) and the use of quinoline esters of Formula (I) in the safe treatment of various s

Factors Which Influence the Formation of Oxadiazoles from Anthranilhydrazides and Other Benzoylhydrazines

The cyclization of o-aminobenzoylhydrazine (1a) and its 5-methyl derivative 1b with four equivalents and with one equivalent of triethyl orthoacetate (TEOA) was studied. 3-Amino-2-methyl-4(3H)-quinazolinone (2a), 3,4-dihydro-2-methyl-5H-1,3,4-benzotriazepin-5-one (3a) and an imino ether derivative of 2a, N-ethanimidic acid ethyl ester (4a) were obtained from the reaction of 1a with four equivalents of TEOA.These results were compared with those of Merour who isolated 2a and 3a using the same conditions.When 1a was treated with one equivalent of TEOA, 2a, 3a, and a new product, 2-(5-methyl-1,3,4-oxadiazol-2-yl)benzenamine (5a) were produced, and 4a was not.Similar results were obtained with the reactions of 1b with TEOA.Authentic samples of oxadiazoles 5a and b were prepared by alternate routes.Novel acid-catalyzed rearrangements of benzotriazepinones 3a and b, to mixtures of aminoquinazolinones 2a and b and oxadiazoles 5a and b, respectively, were found.The different relative amounts of aminoquinazolinones 2 and oxadiazoles 5 which were produced from these rearrangements allowed us to choose between two potential mechanism for these interesting rearrangements.Treatment of 5-nitrobenzoylhydrazine (37) with four equivalents of TEOA gave three products which were characterized, but did not lead to benzotriazepinone formation.