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  • 120279-88-1 Structure
  • Basic information

    1. Product Name: 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
    2. Synonyms: 6-methyl-4-oxo-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide;5,6-Dihydro-6-methylthieno[2,3-b]thiopyran-4-one-2-sulfonamide(DorzolamideIntermediate);(+/-)-6-Methyl-4-oxo-5,6-dihydro-4H-;6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-yl sulfite;5,6-DIHYDRO-6-METHYL-THIENO[2,3-B]THIOPYRAN-4-ONE-2-SULFONAMIDE;()-6-METHYL-4-OXO-5D1,6-DIHYDRO-4H-THIENO[2,3-B]THIOPYRAN-2-SULFONAMIDE;4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 5,6-dihydro-6-methyl-4-oxo-;6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-one 7,7-dioxide
    3. CAS NO:120279-88-1
    4. Molecular Formula: C8H9NO3S3
    5. Molecular Weight: 263.361
    6. EINECS: 1533716-785-6
    7. Product Categories: intermidiate of Dorzolamide
    8. Mol File: 120279-88-1.mol
    9. Article Data: 0
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 520.645 °C at 760 mmHg
    3. Flash Point: 268.677 °C
    4. Appearance: /
    5. Density: 1.543
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.646
    8. Storage Temp.: 2-8°C
    9. Solubility: Ethyl Acetate (Sparingly), Methanol
    10. PKA: 9.63±0.40(Predicted)
    11. CAS DataBase Reference: 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide(120279-88-1)
    13. EPA Substance Registry System: 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide(120279-88-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 120279-88-1(Hazardous Substances Data)

120279-88-1 Usage

Description

6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide is an organic compound that serves as an intermediate in the synthesis of Dorzolamide Hydrochloride, a carbonic anhydrase inhibitor. It is characterized by its unique heterocyclic structure, which includes a thieno[2,3-b]thiopyran ring fused with a sulfonamide group. 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide plays a crucial role in the development of antiglaucoma agents.

Uses

Used in Pharmaceutical Industry:
6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide is used as an intermediate in the synthesis of Dorzolamide Hydrochloride, a carbonic anhydrase inhibitor. It is utilized for the development of antiglaucoma agents, specifically for the treatment of ocular hypertension and open-angle glaucoma. 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide's ability to inhibit carbonic anhydrase leads to a reduction in aqueous humor production, thereby lowering intraocular pressure and alleviating the symptoms associated with these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 120279-88-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,7 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 120279-88:
(8*1)+(7*2)+(6*0)+(5*2)+(4*7)+(3*9)+(2*8)+(1*8)=111
111 % 10 = 1
So 120279-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3S3/c1-4-2-6(10)5-3-7(15(9,11)12)14-8(5)13-4/h3-4H,2H2,1H3,(H2,9,11,12)

120279-88-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methyl-4-oxo-5,6-dihydrothieno[2,3-b]thiopyran-2-sulfonamide

1.2 Other means of identification

Product number -
Other names 4H-Thieno[2,3-b]thiopyran-2-sulfonamide,5,6-dihydro-6-methyl-4-oxo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120279-88-1 SDS

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