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119825-39-7

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119825-39-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 119825-39-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,8,2 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 119825-39:
(8*1)+(7*1)+(6*9)+(5*8)+(4*2)+(3*5)+(2*3)+(1*9)=147
147 % 10 = 7
So 119825-39-7 is a valid CAS Registry Number.

119825-39-7Relevant articles and documents

CARBOHYDRATES AS CHIRAL TEMPLATES: ASYMMETRIC UGI-SYNTHESIS OF ALPHA-AMINO ACIDS USING GALACTOSYLAMINES AS THE CHIRAL MATRICES

Kunz, Horst,Pfrengle, Waldemar

, p. 5487 - 5494 (2007/10/02)

In the presence of Lewis acid catalysts O-acetyl- (1) and O-pivaloyl- (2) protected β-D-galactopyranosylamines react with aldehydes, isocyanides and carboxylic acids in Ugi-four-component-condensations to give the corresponding N-galactosyl-amino acid amide derivatives 3, 5 in almost quantitative yields.Zinc chloride is the most effective Lewis acid catalyst.At 0 deg C or even at room temperature the (2R,β-D)-diastereomers of the amino acid derivatives 3, 5 are formed with high diastereoselectivity.If the sterically more demanding O-pivaloyl galactosylamine 2 is used at -78 deg C to -25 deg C the stereoselectivity often exeeds 20:1 favouring the (2R,β-D) diastereomers 5.After one recrystallisation pure (R)-amino acid derivatives 5 are obtained in yields of 80-95percent.In addition to the high yields and stereoselectivity the amino acid synthesis described here has the further advantage that it neither requires organometallic reagents and intermediates nor exclusion of oxygen and moisture.Two step acid hydrolysis of the N-galactosylamino acid amide derivatives 5 delivers the enantiomerically pure (R)-amino-acids 8 in high yields.

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