1191279-56-7

Basic information

• Product Name: (2-(difluoromethoxy)ethyl)benzene
• Synonyms: (2-(difluoromethoxy)ethyl)benzene
• CAS NO: 1191279-56-7
• Molecular Weight: 172.175
• Mol File: 1191279-56-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-(difluoromethoxy)ethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(difluoromethoxy)ethyl)benzene(1191279-56-7)
• EPA Substance Registry System: (2-(difluoromethoxy)ethyl)benzene(1191279-56-7)

Safety Data

• Hazardous Substances Data: 1191279-56-7(Hazardous Substances Data)

Upstream product

• 60-12-8 2-phenylethanol 
• 77391-96-9 C₉H₁₀Cl₂O 
• 104-62-1 formic acid phenethyl ester 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 

Relevant articles and documents

Difluoromethylation of alcohols with TMSCF2Br in water: A new insight into the generation and reactions of difluorocarbene in a two-phase system

Although many difluorocarbene-involved reactions can be performed in the presence of water, the reaction of difluorocarbene using water as the only reaction medium is rare. By using TMSCF2Br as a unique difluorocarbene reagent and KHF2 as a mild activator, the difluoromethylation of liquid alcohols in water is described. This research not only develops an environmentally benign process for the synthesis of difluoromethyl ethers, but also provides a new insight into the generation and reactions of difluorocarbene in an oil-water two-phase system.

Synthetic method for alkyl difluoromethyl ether compound

The invention discloses a synthetic method for an alkyl difluoromethyl ether compound with convenience, high efficiency, mild conditions, high universality and high operability, and having the advantage of conveniently constructing a difluoromethoxy structure (OCF2H) in the later stage of total synthesis of target molecules. The synthetic method for the alkyl difluoromethyl ether compound is characterized by comprising a difluoromethyl etherification reaction of fatty alcohols and a difluoromethyl etherification reaction of mercaptan: the reagent used in the difluoromethyl etherification reaction of the fatty alcohols is as shown in the formula or an analogue of the formula; and the reagent used in the difluoromethyl etherification reaction of mercaptan is as shown in the formula or an analogue of the formula.

N,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent

Over the past decade, sulfur-based fluoromethyl containing compounds have been exhaustively investigated as versatile fluoroalkylating reagents by our research laboratory as well as many others. Lately, we have designed a novel electrophilic difluoromethylating protocol employing in situ prepared N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium salt. The present reagent provides excellent reactivity toward a broad spectrum of nucleophilic species (N-, P-, S-, and O-nucleophiles) to yield the corresponding difluoromethylated products with high efficacy under mild conditions. Additional studies have been performed to elucidate the mechanistic fundamentals of the reactions.