118933-92-9

Basic information

• Product Name: 1-Methyl-6-hydroxy-1H-indazole
• Synonyms: 1-Methyl-6-hydroxy-1H-indazole;6-Hydroxy-1-methyl-1H-indazole;1-Methyl-1H-indazol-6-ol;6-hydroxy-1-methyl-1H-indazole, 1-methyl-6-hydroxyindazole, 1-methyl-1H-indazol-6-ol, 1-methyl-1H-indazol-6-ol
• CAS NO: 118933-92-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16192
• Mol File: 118933-92-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-6-hydroxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-6-hydroxy-1H-indazole(118933-92-9)
• EPA Substance Registry System: 1-Methyl-6-hydroxy-1H-indazole(118933-92-9)

Safety Data

• Hazardous Substances Data: 118933-92-9(Hazardous Substances Data)

Usage

Description

1-Methyl-6-hydroxy-1H-indazole is a chemical compound with the molecular formula C8H8N2O. It is an indazole derivative characterized by the presence of a hydroxy group at the 6-position and a methyl group at the 1-position of the indazole ring. 1-Methyl-6-hydroxy-1H-indazole possesses unique structural features and bioactive properties, making it a promising candidate for pharmaceutical research and drug development.

Uses

Used in Pharmaceutical Research and Drug Development:
1-Methyl-6-hydroxy-1H-indazole is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure and bioactive properties allow it to be explored for the development of new drugs targeting various diseases and conditions.
Used in Industrial Applications:
1-Methyl-6-hydroxy-1H-indazole may also have various industrial uses, such as in the synthesis of other chemical compounds or as an intermediate in chemical reactions. However, further research and testing are required to determine its full range of applications and potential benefits in these areas.

Upstream product

• 7597-18-4 6-nitroindazole 
• 6850-23-3 1-methyl-6-nitro-1H-indazole 
• 74728-65-7 1-methyl-1H-indazol-6-ylamine 

Relevant articles and documents

Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors

The Wnt signaling pathway is a pivotal developmental pathway. It operates through control of cellular functions such as proliferation, differentiation, migration and polarity. Aberrant Wnt signaling has been implicated in the formation and metastasis of tumors. Porcupine is a component of the Wnt signaling pathway. It is a member of the membrane-bound O-acyltransferase family of proteins. Porcupine catalyzes the palmitoylation of Wnt proteins, a process which is essential to their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from two known porcupine inhibitor classes. The leading compound 62 demonstrated subnanomolar (IC50 0.11 nM) inhibition of Wnt signaling in a paracrine cellular reporter gene assay. Compound 62 also potently inhibited Wnt secretion into culture medium, an indication of direct inhibition of the porcupine protein. Furthermore, compound 62 showed excellent chemical, plasma and liver microsomal stabilities. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

Wnt signal pathway inhibitor and use thereof

The invention relates to heterocyclic compounds with Wnt signal channel inhibition activity, particularly including compounds, pharmaceutically acceptable salts, various isotopes, various isomers or various crystal structures thereof having a structure represented by a general formula I (shown in the specification). By the compounds and a composition of the compounds, a Wnt signal channel can be effectively inhibited and diseases related to the Wnt signal channel can be treated or prevented.

SYNTHESIS OF 5-HYDROXY-4-NITROSOBENZOTRIAZOLES AND 6-HYDROXY-7-NITROSO-INDAZOLES AND THEIR SPLITTING INTO β-TRIAZOLYL- AND β-PYRAZOLYLACRYLIC ACIDS

5-Hydroxy-4-nitrosobenzotriazoles and 6-hydroxy-7-nitrosoindazoles were synthesized.By the action of benzenesulfonyl chloride in an alkaline medium, only 5-hydroxy-4-nitroso-2-phenyl-benzotriazole and 1-methyl-6-hydroxy-7-nitrosoindazole split into 5-carb