1184936-95-5Relevant articles and documents
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists
O'Donnell, Christopher J.,Peng, Langu,O'Neill, Brian T.,Arnold, Eric P.,Mather, Robert J.,Sands, Steven B.,Shrikhande, Alka,Lebel, Lorraine A.,Spracklin, Douglas K.,Nedza, Frank M.
scheme or table, p. 4747 - 4751 (2010/06/13)
The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of α7 nAChR agonists is described. The development of the medicinal chemistry strategy and SAR which led to the identification of 5 and 7aa as subtype selective, high affinity α7 agonists as excellent leads for further evaluation is discussed, along with key physicochemical and pharmacokinetic data highlighting their lead potential.
