1172623-98-1

Basic information

• Product Name: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate
• Synonyms: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate;N-[(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]-Carbamic acid 1,1-dimethylethyl ester;Carbamic acid, N-[(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]-, 1,1-dimethylethyl ester;Omarigliptin Impurity 1
• CAS NO: 1172623-98-1
• Molecular Formula: C₁₆H₁₉F₂NO₃
• Molecular Weight: 311.3237664
• EINECS: -0
• Product Categories: Omarigliptin
• Mol File: 1172623-98-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 395.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 11.18±0.40(Predicted)
• CAS DataBase Reference: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate(1172623-98-1)
• EPA Substance Registry System: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate(1172623-98-1)

Safety Data

• Hazardous Substances Data: 1172623-98-1(Hazardous Substances Data)

Usage

Description

Tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate is a carbamate derivative with a molecular formula C16H23F2NO3. It features a tert-butyl group and a pyran ring structure, which may contribute to its potential biological activities. This chemical compound is of interest in the field of medicinal chemistry, particularly for the development of pharmaceutical drugs.

Uses

Used in Pharmaceutical Development:
Tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate is used as a chemical intermediate for the development of pharmaceutical drugs. Its unique structure and properties make it a promising candidate for further research and exploration in various medical applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran-3-yl]carbaMate is used as a subject of interest for investigating its potential biological activities and applications. Its structural features may provide insights into the design and synthesis of new drugs with improved therapeutic effects.

Upstream product

• 1172623-95-8 (±)-tert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1172623-96-9 (±)-tert-butyl (1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-yl)carbamate 
• 50428-03-0 D,L-propargylglycine 
• 61172-66-5 2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid 
• 61172-66-5 (S)-2-(tert-butoxycarbonylamino)pent-4-ynoic acid 
• 208520-80-3 (S)-tert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate 
• 100860-41-1 ethyl 2-aminopent-4-ynoate 
• 167904-79-2 methyl (R,S)-2-(N-diphenylmethylidene)aminopent-4-ynoate 

Downstream Products

• 1172623-99-2 tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl]carbamate 
• 951127-25-6 N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester 
• 1226781-44-7 Omarigliptin 
• 1226781-87-8 tert-butyl {(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 

Relevant articles and documents

Ternary fused ring substituted six-membered ring derivatives and their use in medicine

The invention relates to a fused tricyclic substituted amino six-membered ring derivative and application thereof in medicine, particularly a fused tricyclic substituted amino six-membered ring derivative shown in a formula (I) or stereoisomers and pharmaceutically acceptable salts or pro-drugs of the derivative, a pharmaceutical composition comprising the derivative and use of the derivative in preparing a dipeptidyl peptidase IV (DPP-IV) inhibitor in medicine, wherein the substituents in the formula (I) are defined as in the description. The formula (I) is shown in the description.

Amino 6-membered ring derivative and pharmaceutical applications thereof including the use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor

The present invention relates to an amino 6-membered ring derivative and pharmaceutical applications thereof, which specifically relates to the amino 6-membered ring derivative represented by the general formula (I) or stereoisomers thereof, pharmaceutically acceptable salts thereof, a prodrug, a pharmaceutical composition comprising the derivative, and the pharmaceutical use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor, wherein the definition of each substituent in the general formula (I) is the same as described in the specification.

Pyrrole imidazole ring derivative and medical use thereof wherein the compound represented by the general formula (I) has excellent inhibitory effect on and selectivity of dipeptidyl peptidase IV(DPP-IV)

The present invention relates to a pyrrole imidazole ring derivative and medical use thereof, more particularly a pyrrole imidazole ring derivative represented by the general formula (I) or stereoisomers thereof, pharmaceutically acceptable salts thereof, prodrugs, pharmaceutical compositions containing the derivative, and pharmaceutical applications for the preparation of dipeptidyl peptidase IV(DPP-IV) inhibitors, wherein the definitions of all substitution groups in general formula (I) are the same as those defined in the specification.