1170667-83-0Relevant articles and documents
The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption
Huttunen, Kristiina M.,Mannila, Anne,Laine, Krista,Kemppainen, Eeva,Leppanen, Jukka,Vepsalainen, Jouko,Jarvinen, Tomi,Rautio, Jarkko
, p. 4142 - 4148 (2009)
Metformin is a potent antidiabetic agent and currently used as a first-line treatment for patients with type 2 diabetes. Unfortunately, the moderate absorption and uncomfortable gastrointestinal adverse effects associated with metformin therapy impair its