1169707-30-5 Usage
Description
(3R)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-1-butanone is a complex chemical compound featuring a butanone core with a trifluoromethyl-substituted pyrazino-triazole ring and an amino group attached to a phenylethyl group. Its fluoro-substituted aromatic rings and unique structural features suggest potential pharmacological properties and interactions with biological targets.
Uses
Used in Pharmaceutical Industry:
(3R)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-1-butanone is used as a potential pharmaceutical compound for its possible interactions with biological targets, which may lead to the development of new drugs or therapies. Further research is required to explore its pharmacological properties and mechanisms of action.
Used in Chemical Research:
In the field of chemical research, (3R)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-1-butanone may serve as a starting material or a structural component in the synthesis of novel compounds with potential applications in various industries, including materials science, agrochemicals, and more. Its unique structure could provide insights into new chemical reactions and bonding mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 1169707-30-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,9,7,0 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1169707-30:
(9*1)+(8*1)+(7*6)+(6*9)+(5*7)+(4*0)+(3*7)+(2*3)+(1*0)=175
175 % 10 = 5
So 1169707-30-5 is a valid CAS Registry Number.
InChI:InChI=1S/C24H23F6N5O/c1-14(15-5-3-2-4-6-15)31-17(9-16-10-19(26)20(27)12-18(16)25)11-22(36)34-7-8-35-21(13-34)32-33-23(35)24(28,29)30/h2-6,10,12,14,17,31H,7-9,11,13H2,1H3/t14-,17-/m1/s1
1169707-30-5Relevant articles and documents
A west he row sandbank and intermediate preparation method
-
, (2017/08/25)
The invention relates to the field of medicament synthesis and especially relates to a preparation method of sitagliptin and an intermediate thereof. The preparation method of a compound show as formula III is as below: in the presence of a first organic solvent, a compound shown as formula I and a compound shown as formula II conduct reductive amination reaction under the action of a reducing agent and organic acid, so as to obtain the compound shown in formula III. The preparation method provided by the invention does not use precious metal as the catalyst, reduces the cost, simplifies the synthesis process, increases the yield, and improves the chemical purity and optical purity of sitagliptin. R represents methyl or carbamyl, and Ar represents phenyl, monosubstituted phenyl or polysubstituted phenyl.
EXPEDIENT SYNTHESIS OF SITAGLIPTIN
-
, (2015/09/23)
Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.
Practical and economical approach to synthesize sitagliptin
Lin, Kuaile,Cai, Zhengyan,Zhou, Weicheng
, p. 3281 - 3286 (2013/10/01)
Economic syntheses of sitagliptin phosphate monohydrate, acknowledged as the first dipeptidyl peptidase 4 (DPP-4) inhibitor, have been achieved in an overall yield of 42.4% in four steps from 1-{3-(trifluoromethyl)-5,6-dihydro-[1, 2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)butane-1,3-dione. The key stereoselective reduction of this process was carried out by NaBH 4/HCOOH instead of expensive and toxic catalysts or ligands. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
