114736-25-3

Basic information

• Product Name: 2-Butenoic acid, 4,4-
• Synonyms: 2-Butenoic acid, 4,4-;(2E)-4,4-Dimethoxybut-2-enoic acid ethyl ester;(E)-4,4-Dimethoxy-2-butenoic acid ethyl ester;Ethyl (E)-4,4-dimethoxy-2-butenoate;2-Butenoic acid, 4,4-diMethoxy-, ethyl ester;(E)-Ethyl 4,4-DiMethoxybut-2-enoate;ethyl 4,4-diMethoxybut-2-enoate;Ethyl(E)-4,4-dimethoxybut-2-enoate
• CAS NO: 114736-25-3
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.19436
• EINECS: -0
• Mol File: 114736-25-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 222℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.019
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-Butenoic acid, 4,4-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4,4-(114736-25-3)
• EPA Substance Registry System: 2-Butenoic acid, 4,4-(114736-25-3)

Safety Data

• Hazardous Substances Data: 114736-25-3(Hazardous Substances Data)

Usage

Description

2-Butenoic acid, 4,4-, also known as (E)-Ethyl 4,4-Dimethoxybut-2-enoate, is an organic compound with a unique structure that features a butenoic acid backbone and two methoxy groups at the 4th position. It is characterized by its reactivity and potential for use in various chemical reactions and syntheses.

Uses

Used in Pharmaceutical Industry:
2-Butenoic acid, 4,4is used as a reactant for the synthesis of N-substituted-1,2,3,6-tetrahydro-pyridine-4-carbaldehyde, which is a crucial precursor for the production of Aricept. Aricept, also known as Donepezil, is a medication used to treat Alzheimer's disease and other cognitive impairments. The compound's role in the synthesis of Aricept highlights its importance in the development of therapeutic agents for neurological conditions.

Upstream product

• 64-17-5 ethanol 
• 18778-96-6 (2E)-4,4-dimethoxybut-2-enal 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 51673-84-8 dimethoxyacetaldehyde 

Downstream Products

• 1150567-97-7 (6-phenethyl-imidazo[1,2-b]pyridazin-3-yl)-acetic acid 
• 7328-34-9 ethyl 2E,4E-decadienoate 
• 3025-30-7 ethyl (2E,4Z)-2,4-decadienoate 
• 101820-69-3 imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester 
• 2960-66-9 4-oxo-but-2-enoic acid ethyl ester 
• 808141-23-3 1-benzyl-3-(3,4-dimethoxybenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-20-0 4-[1-benzyl-4-dimethoxymethyl-2-oxo-3-(toluene-4-sulfonyl)piperidin-3-ylmethyl]benzoic acid methyl ester 
• 808141-13-1 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-15-3 1-benzyl-3-(2-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-16-4 1-benzyl-3-(4-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-17-5 1-benzyl-4-dimethoxymethyl-3-thiophen-2-ylmethyl-3-(toluene-4-sulfonyl)-piperidin-2-one 
• 808141-08-4 1-benzyl-4-dimethoxymethyl-3-(2-methylallyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 640722-73-2 1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 

Relevant articles and documents

Organocatalyzed Michael-Henry reactions: Enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protei kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

SYNTHESE STEREOSELECTIVE DU DECADIENE-2(E), 4(Z)OATE D'ETHYLE. A PARTIR D'UN MONOACETAL DU GLYOXAL

The glyoxal monoacetal 2, now readily available in bulk quantity, is a very useful synthon for the dienes-1,3 synthesis, as illustrated in the stereoselective preparation of ethyl 2E,4Z-decadienoate using two Wittig-type olefination reactions.