114715-77-4

Basic information

• Product Name: 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID
• Synonyms: 2-HYDROXY-2-(TRIFLUOROMETHYL)PROPIONIC ACID;2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID;2-(TRIFLUOROMETHYL)LACTIC ACID;3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID;3,3,3-TRIFLUORO-2-HYDROXYISOBUTYRIC ACID;RARECHEM AL BO 0412;TFM-LA;2-(Trifluoromethyl)-2-hydroxypropionic acid~2-(Trifluoromethyl)lactic acid
• CAS NO: 114715-77-4
• Molecular Formula: C₄H₅F₃O₃
• Molecular Weight: 158.08
• EINECS: -0
• Mol File: 114715-77-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 85°C
• Boiling Point: 189°C
• Flash Point: 189°C
• Appearance: /
• Density: 1.532 g/cm³
• BRN: 1723691
• CAS DataBase Reference: 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID(114715-77-4)
• EPA Substance Registry System: 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID(114715-77-4)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 114715-77-4(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)-2-hydroxypropionic acid is a chemical compound characterized by the presence of both trifluoromethyl and carboxylic acid functional groups. This molecule is structurally similar to other alpha-hydroxy acids (AHAs), which are widely used in the cosmetics industry for their exfoliating and skin-smoothing properties. Its trifluoromethyl group increases the compound's stability and lipophilicity, potentially enhancing its skin absorption. Despite these desirable properties, there is limited information available about this specific compound's use or safety in cosmetic or other formulations, necessitating further research.

Upstream product

• 337-16-6 2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester 
• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 
• 693287-30-8 (R)-2,3-epoxy-2-(trifluoromethyl)propionic acid 
• 374-35-6 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 

Downstream Products

• 243982-46-9 (R)-N-(2-Chlorophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329794-58-3 (R)-[5-(4-methylsulphanylphenylsulphanyl)-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)indoline] 
• 1360607-89-1 4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)thio)N,N-dimethylbenzamide 

Relevant articles and documents

Efficient preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2- methylpropanoic acid catalyzed by Shinella sp. R-6 and Arthrobacter sp. S-2

Several microorganisms that can enantioselectively hydrolyze 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide have been isolated from soil samples. These strains were capable of growing in a medium containing 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide as the sole nitrogen source. Among them, Shinella sp. R-6 was identified as a strain capable of exhibiting R-selective hydrolysis activity, while Arthrobacter sp. S-2 was capable of exhibiting S-selective hydrolysis activity. The preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid via the two-step whole-cell reaction was investigated using these two strains.

Optically active fluorine-containing compounds and processes for their production

An optically active fluorine-containing compound represented by the following formula (1) or (2) wherein A is an oxygen atom, a sulfur atom or an NH group, and R1 selected from a variety of organic group, is used in the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid.

Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof

There are disclosed are a diastereomer salt of formula (1): a process for producing the same, a process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formula (2′): a novel optically active amine compound of formula (4): a novel optically active amine compound of formula (8): an imine compound of formula (7) or (11):