1146629-74-4

Basic information

• Product Name: (R)-2-(bis(3,5-bis(trifluoroMethyl)phenyl)(tert-butyldiMethylsilyloxy)Methyl)pyrrolidine
• Synonyms: (R)-2-(bis(3,5-bis(trifluoroMethyl)phenyl)(tert-butyldiMethylsilyloxy)Methyl)pyrrolidine;R-2-[bis[3,5-bis(trifluoroMethyl)phenyl][[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-Pyrrolidine;Pyrrolidine, 2-[bis[3,5-bis(trifluoroMethyl)phenyl][[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-, (2R)-;(2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl][[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyrrolidine;(R)-2-{Bis[3,5-bis(trifluoromethyl)phenyl](tert-butyldimethylsilanyloxy)methyl}pyrrolidine;(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol tert-butyldimethylsilyl ether;(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]prolinol tert-butyldimethylsilyl ether;(2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]-[(tertbutyldimethylsilyl) oxy]methyl]pyrrolidine
• CAS NO: 1146629-74-4
• Molecular Formula: C₂₇H₂₉F₁₂NOSi
• Molecular Weight: 639.5915984
• Mol File: 1146629-74-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 419.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.45±0.10(Predicted)
• CAS DataBase Reference: (R)-2-(bis(3,5-bis(trifluoroMethyl)phenyl)(tert-butyldiMethylsilyloxy)Methyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(bis(3,5-bis(trifluoroMethyl)phenyl)(tert-butyldiMethylsilyloxy)Methyl)pyrrolidine(1146629-74-4)
• EPA Substance Registry System: (R)-2-(bis(3,5-bis(trifluoroMethyl)phenyl)(tert-butyldiMethylsilyloxy)Methyl)pyrrolidine(1146629-74-4)

Safety Data

• Hazard Codes: C,N
• Statements: 22-37/38-41-54
• Safety Statements: 26-39
• Hazardous Substances Data: 1146629-74-4(Hazardous Substances Data)

Usage

General Description

"(R)-2-(bis(3,5-bis(trifluoromethyl)phenyl)(tert-butyldimethylsilyloxy)methyl)pyrrolidine" is a complex chemical compound with a pyrrolidine ring structure and several functional groups attached. It is a chiral molecule, with the (R) configuration indicating its specific arrangement of atoms. The compound contains multiple trifluoromethyl groups, which are known for their strong electron-withdrawing properties. Additionally, it features a tert-butyldimethylsilyloxy group, which can act as a protective group in organic synthesis. The presence of these groups indicates that the compound may have applications in pharmaceuticals, materials science, or other areas of chemical research. Its unique structure and functional groups make it a valuable target for further study and potential use in various industries.

Upstream product

• 948595-00-4 (R)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol 
• 69739-34-0 t-butyldimethylsiyl triflate 

Relevant articles and documents

PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS

The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.