1146618-41-8 Usage
Uses
Used in Pharmaceutical Industry:
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) is used as a pharmaceutical compound for the development of new drugs targeting various diseases. Its unique chemical structure allows it to interact with specific biological targets, making it a promising candidate for the treatment of conditions such as cancer, inflammation, and other disorders.
Used in Chemical Research:
In the field of chemical research, N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) serves as a valuable starting material or intermediate for the synthesis of other complex organic molecules. Its versatile structure can be further modified or functionalized to create new compounds with improved properties or novel applications.
Used in Drug Delivery Systems:
Similar to gallotannin, N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) can be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound can be more effectively targeted to specific cells or tissues, improving its overall efficacy and reducing potential side effects.
References
1) Oslob?et al.?(2008)?Discovery of a potent and selective aurora kinase inhibitor; Bioorg. Med. Chem. Lett.?18?4880
2) Arbitrario?et al.?(2010)?SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo; Cancer Chemother. Pharmacol.?65?707
3) VanderPorten?et al.?(2009)?The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model; Mol. Cancer Ther.?8?930
4) Liu?et al.?(2017)?Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma; Oncotarget?8?27953
Check Digit Verification of cas no
The CAS Registry Mumber 1146618-41-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,6,1 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1146618-41:
(9*1)+(8*1)+(7*4)+(6*6)+(5*6)+(4*1)+(3*8)+(2*4)+(1*1)=148
148 % 10 = 8
So 1146618-41-8 is a valid CAS Registry Number.
1146618-41-8Relevant articles and documents
AURORA KINASE INHIBITORS
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, (2009/10/22)
The present invention provides Compound 1: (Formula should be inserted here) solid forms thereof, compositions thereof, and methods of using the same. The present invention also provides synthetic methods of preparing Compound 1 and intermediates thereto.
