114659-77-7

Basic information

• Product Name: (E)-N’-(3'-hydroxybenzylidene)nicotinohydrazide
• Synonyms: (E)-N’-(3'-hydroxybenzylidene)nicotinohydrazide
• CAS NO: 114659-77-7
• Molecular Weight: 241.249
• Mol File: 114659-77-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-N’-(3'-hydroxybenzylidene)nicotinohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N’-(3'-hydroxybenzylidene)nicotinohydrazide(114659-77-7)
• EPA Substance Registry System: (E)-N’-(3'-hydroxybenzylidene)nicotinohydrazide(114659-77-7)

Safety Data

• Hazardous Substances Data: 114659-77-7(Hazardous Substances Data)

Upstream product

• 553-53-7 Nicotinic acid hydrazide 
• 100-83-4 meta-hydroxybenzaldehyde 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Relevant articles and documents

Antimicrobial activities of synthetic arylidine nicotinic and isonicotinic hydrazones

Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities. Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures. Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives

A series of nicotinic acid benzylidene hydrazide derivatives (1-18) was synthesized and tested in vitro for biological evaluations. The antimycobacterial activity results indicated that the presence of electron-withdrawing halogen groups at para position of the phenyl ring improved their activity. The results of antiviral evaluation depicted that none of the synthesized derivatives inhibited the replication of viruses at subtoxic concentration. Further, the antimicrobial screening results indicated that compounds having OCH3 and NO2 substituents were the most active ones. QSAR investigations revealed that multitarget QSAR models were effective in describing the antimicrobial activity. Springer Science+Business Media, LLC 2011.