1137423-90-5

Basic information

• Product Name: 2-{[3-(1,3-benzodioxol-5-yl)-4-oxo-4H-1-benzopyran-7-yl]oxy}acetic acid
• Synonyms: 2-{[3-(1,3-benzodioxol-5-yl)-4-oxo-4H-1-benzopyran-7-yl]oxy}acetic acid
• CAS NO: 1137423-90-5
• Molecular Weight: 340.289
• Mol File: 1137423-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{[3-(1,3-benzodioxol-5-yl)-4-oxo-4H-1-benzopyran-7-yl]oxy}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[3-(1,3-benzodioxol-5-yl)-4-oxo-4H-1-benzopyran-7-yl]oxy}acetic acid(1137423-90-5)
• EPA Substance Registry System: 2-{[3-(1,3-benzodioxol-5-yl)-4-oxo-4H-1-benzopyran-7-yl]oxy}acetic acid(1137423-90-5)

Safety Data

• Hazardous Substances Data: 1137423-90-5(Hazardous Substances Data)

Upstream product

• 90-29-9 7-hydroxy-3',4'-methylenedioxyisoflavone 

Relevant articles and documents

Novel daidzein analogs and their in vitro anti-influenza activities

A series of novel isoflavonoids were synthesized based on structural modifications of daidzein, an active ingredient of traditional Chinese medicine (TCM) and evaluated for their anti-influenza activity, in vitro, against H1N1 Tamiflu-resistant (H1N1 TR) virus in the MDCK cell line. Among them, 4-oxo-4H-1-benzopyran-8-carbaldehydes 11a-11g were most promising, and they demonstrated better activities and selectivities comparable to those the reference ribarivin, a nucleoside antiviral agent. 3-(4-Bromophenyl)-7-hydroxy-4-oxo-4H-1-benzopyran-8-carboxaldehyde (11c) displayed the best inhibitory activity (EC50, 29.0 μM) and selectivity index (SI>10.3). Analysis of the structure￡activity relationships (SAR) indicated that both the non-naturally-occurring Br-substituted B-ring and appropriate CHO and OH groups on the A-ring might be critical for the activity and selectivity against H1N1 TR influenza viruses.