113293-70-2

Basic information

• Product Name: 2,6-Dichloropyridine-4-carboxaldehyde
• Synonyms: 2,6-DICHLOROISONICOTINALDEHYDE;2,6-DICHLOROPYRIDINE-4-CARBOXALDEHYDE;2,6-DICHLORO-4-FORMYL PYRIDINE;2,6-DICHLORO-4-PYRIDINECARBOXALDEHYDE;2,6-Dichloro-4-formyl pyeidine;2,6-Dichloropyridine-4-carboxaldehyde ,98%;2,6-dichloro-3-forMylpyridine-4-carboxylic acid;6-dichloropyridine-4-carbaldehyde
• CAS NO: 113293-70-2
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• Product Categories: pharmacetical;Aldehydes;Pyridines
• Mol File: 113293-70-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 47-48°C
• Boiling Point: 276.685 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.39±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloropyridine-4-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloropyridine-4-carboxaldehyde(113293-70-2)
• EPA Substance Registry System: 2,6-Dichloropyridine-4-carboxaldehyde(113293-70-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 113293-70-2(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow solid

InChI:InChI=1/C6H3Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-3H

Upstream product

• 42521-08-4 2,6-dichloroisonicotinoyl chloride 
• 2591-86-8 N-Formylpiperidine 
• 2402-78-0 2,6-dichloropyridine 
• 101990-69-6 (2,6-dichloropyridin-4-yl)methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 99-11-6 citrazinic acid 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 1604-14-4 2,6-dichloroisonicotinic acid ethyl ester 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 

Downstream Products

• 101990-69-6 (2,6-dichloropyridin-4-yl)methanol 
• 211183-10-7 C₂₀H₁₉N₃O₅S₂ 
• 1201675-01-5 2,6-dichloro-4-(difluoromethyl) pyridine 
• 1239363-46-2 (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(oxazol-5-yl)pyridin-2-amine 
• 1239358-92-9 (S)-N²-[1-(4-fluorophenyl)ethyl]-4-(imidazooxazole-5-yl)-N⁶-(aminopyrazine-2-yl)-2,6-diamine 
• 1201673-57-5 cyclohexyl-(4-difluoromethyl-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)amine 
• 1201673-40-6 tert-butyl 4-(2'-(cyclohexylamino)-4-(difluoromethyl)-2,4'-bipyridin-6-yl)piperazine-1-carboxylate 
• 1390656-68-4 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-2-methylphenyl)piperazine-1-carboxylate 

Relevant articles and documents

2 Tyrosine kinase mediated signal transduction inhibitors

Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

Preparation and use of magnesium amides

The present application relates to mixed Mg/Li amides of the general formula ???????? R1R2N-MgX·zLiY?????(I), wherein R1, R2 and R3 independently are selected from substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, and, for R1 and R2 only, the silyl derivatives thereof; one of R1 and R2 may be H; or R1 and R2 together can be part of a cyclic or polymeric structure; X and Y independently are selected amongst others from the group consisting of F; Cl; Br; I; CN; SCN; NCO; and z > 0, as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.