1124321-01-2Relevant articles and documents
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections
Macleod, Angus M.,Mitchell, Dale R.,Palmer, Nicholas J.,Van De Poel, Herve,Conrath, Katja,Andrews, Martin,Leyssen, Pieter,Neyts, Johan
, p. 585 - 589 (2013/07/26)
Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIIIβ. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.