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  • 1119-97-7 Structure
  • Basic information

    1. Product Name: Cetrimide
    2. Synonyms: alkyl*trimethylammoniumbromide*(c14,5%c16);alkyltrimethylammoniumbromide;alkyltrimethylammoniumbromide(c14,5%c16);Tetradecanaminium,N,N,N-trimethyl-,bromide;tetradecyltrimethyl-ammoniubromide;tetradonium;tetradoniumbromide;trimethyltetradecyl-ammoniubromide
    3. CAS NO:1119-97-7
    4. Molecular Formula: Br*C17H38N
    5. Molecular Weight: 336.39
    6. EINECS: 214-291-9
    7. Product Categories: Ammonium Bromides (Quaternary);Quaternary Ammonium Compounds;Pharmaceutical raw materials
    8. Mol File: 1119-97-7.mol
    9. Article Data: 6
  • Chemical Properties

    1. Melting Point: 245-250 °C(lit.)
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: White/Fine Crystalline Powder
    5. Density: 1.1328 (rough estimate)
    6. Vapor Pressure: 0Pa at 25℃
    7. Refractive Index: 1.5260 (estimate)
    8. Storage Temp.: +2C to +8C
    9. Solubility: H2O: 10 % (w/v)
    10. Water Solubility: 20 g/100 mL
    11. Sensitive: Hygroscopic
    12. Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents.
    13. Merck: 14,6336
    14. BRN: 3633227
    15. CAS DataBase Reference: Cetrimide(CAS DataBase Reference)
    16. NIST Chemistry Reference: Cetrimide(1119-97-7)
    17. EPA Substance Registry System: Cetrimide(1119-97-7)
  • Safety Data

    1. Hazard Codes: C
    2. Statements: 34
    3. Safety Statements: 26-36/37/39-45-27
    4. RIDADR: UN 3263 8/PG 2
    5. WGK Germany: 3
    6. RTECS: BS5776000
    7. F: 3
    8. TSCA: Yes
    9. HazardClass: 8
    10. PackingGroup: II
    11. Hazardous Substances Data: 1119-97-7(Hazardous Substances Data)

1119-97-7 Usage

Description

Cetrimide, also known as Myristyltrimethylammonium bromide, is a cationic/zwitterionic type of surfactant. It is a white fine powder crystal with a melting point of 245°C to 250°C and a rough estimate of its density is 1.1328. Cetrimide is soluble in water with a solubility of 20 g/100 mL. It is a dynamin I/II inhibitor that targets the dynamin-phospholipid interaction and inhibits dynamin GTPase activity with a Ki=940nM. It rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage, making it a useful pharmacological tool for studying dynamin-mediated trafficking events. Additionally, it induces cytokinesis failure and apoptosis in human cancer cells and induces cytoprotective autophagy in human Jurkat T cells.

Uses

Used in Disinfectant Applications:
Cetrimide is used as a disinfectant for its ability to inhibit the growth of microorganisms and prevent the spread of infections.
Used in Deodorant Applications:
Cetrimide is used as a deodorant due to its effectiveness in controlling and eliminating unpleasant odors.
Used in Laboratory Reagent Applications:
Cetrimide is used as a laboratory reagent in various scientific research and experiments, particularly in the study of dynamin-mediated trafficking events and its effects on cancer cells.
Used in Surfactant-Controlled Synthesis:
Cetrimide, specifically Myristyltrimethylammonium, has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.
Used in Soil and Plant Analysis:
Cetrimide has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis, contributing to the understanding of soil and plant health.

Purification Methods

Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]

References

1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425 2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78 3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010 4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609

Check Digit Verification of cas no

The CAS Registry Mumber 1119-97-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,1 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1119-97:
(6*1)+(5*1)+(4*1)+(3*9)+(2*9)+(1*7)=67
67 % 10 = 7
So 1119-97-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1

1119-97-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L10294)  (1-Tetradecyl)trimethylammonium bromide, 98%   

  • 1119-97-7

  • 25g

  • 115.0CNY

  • Detail
  • Alfa Aesar

  • (L10294)  (1-Tetradecyl)trimethylammonium bromide, 98%   

  • 1119-97-7

  • 100g

  • 286.0CNY

  • Detail
  • Alfa Aesar

  • (L10294)  (1-Tetradecyl)trimethylammonium bromide, 98%   

  • 1119-97-7

  • 500g

  • 903.0CNY

  • Detail
  • Sigma-Aldrich

  • (87208)  Myristyltrimethylammoniumbromide  for ion pair chromatography, ≥99.0% (AT)

  • 1119-97-7

  • 87208-10G

  • 1,664.91CNY

  • Detail
  • Sigma-Aldrich

  • (T2450000)  Trimethyltetradecylammonium bromide  European Pharmacopoeia (EP) Reference Standard

  • 1119-97-7

  • T2450000

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (87210)  Myristyltrimethylammoniumbromide  98% (AT)

  • 1119-97-7

  • 87210-100G

  • 524.16CNY

  • Detail
  • Sigma-Aldrich

  • (87210)  Myristyltrimethylammoniumbromide  98% (AT)

  • 1119-97-7

  • 87210-500G

  • 1,440.27CNY

  • Detail

1119-97-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Cetrimide

1.2 Other means of identification

Product number -
Other names N,N,N-TRIMETHYL-1-TETRADECANAMINIUM BROMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1119-97-7 SDS

1119-97-7Related news

Basic ResearchResidual Activity of Chelating Agents and their Combinations with Cetrimide (cas 1119-97-7) on Root Canals Infected with Enterococcus faecalis09/29/2019

IntroductionThe use of chelating agents in endodontic treatment is required to remove the smear layer and to achieve better disinfection within the root canal system. The aim of this study was to evaluate the residual antimicrobial activity of 17% ethylenediaminetetraacetic acid (EDTA), 7% malei...detailed

Basic ResearchAntimicrobial Activity of Maleic Acid and Combinations of Cetrimide (cas 1119-97-7) with Chelating Agents against Enterococcus Faecalis Biofilm10/01/2019

IntroductionChelating agents, such as EDTA or citric acid, can be incorporated into irrigants in order to provide different properties in a single compound. Maleic acid has recently been proposed as an alternative irrigant to EDTA given its better smear layer removal and biocompatibility; howeve...detailed

Synthesis and characterization of porous shell-like nano hydroxyapatite using Cetrimide (cas 1119-97-7) as template09/26/2019

Macromolecules of various surfactants and polymers are being used to prepare nano hydroxyapatites (HAp) of varied morphology. Here we report the successful preparation of shell-like nano HAp spheres with fine morphology, uniform size around 200 nm, and stoichiometry ratio 1.7 with 56% nano- (detailed

On-plate spot test for identification and separation of benzalkonium chloride and Cetrimide (cas 1119-97-7) in drug samples: A mechanistic view09/24/2019

A mechanism showing different modes of interaction of benzalkonium chloride and cetrimide with the stationary and mobile phase has been proposed which leads to the separation of this surfactant mixture. Other combination of cationic surfactants was also separated from their binary mixture by the...detailed

Basic ResearchEradication of Enterococcus faecalis Biofilms by Cetrimide (cas 1119-97-7) and Chlorhexidine09/10/2019

IntroductionEnterococcus faecalis is the most commonly isolated bacteria from root canals of teeth with persistent periapical periodontitis. Its ability to grow as a biofilm impedes the elimination of E. faecalis by using irrigating solutions. The purpose of this study was to assess the efficacy...detailed

Studies on the selectivity of Cetrimide (cas 1119-97-7) for uranium extraction from wet process phosphoric acid09/09/2019

Cetrimide was proven to be an effective selective extractant for uranium from phosphoric acid solutions of comparable concentration to the wet process phosphoric acid (WPPA). Several experiments have thus been performed to determine the relevant factors of both uranium extraction and stripping u...detailed

1119-97-7Relevant articles and documents

Kinetics of hydrolysis of procaine in aqueous and micellar media

Al-Blewi, Fawzia Faleh,Al-Lohedan, Hamad A.,Rafiquee,Issa, Zuheir A.

, p. 1 - 9 (2013/01/15)

The kinetics of alkaline hydrolysis of procaine under the pseudo-first-order condition ([OH-] a [procaine]) has been carried out. N,N-Diethylaminoethanol and p-aminobenzoate anion were obtained as the hydrolysis product. The rate of hydrolysis was found to be linearly dependent upon [NaOH]. The addition of cationic cetyltrimethylammonium bromide (CTAB), dodecyltrimethylammonium bromide (DDTAB) and tetradecyltrimethylammonium bromide, and anionic sodium dodecyl sulfate (SDS) micelles inhibited the rate of hydrolysis. The maximum inhibitive effect on the reaction rate was observed for SDS micelles, whereas among the cationic surfactants, CTAB inhibited most. The variation in the rate of hydrolysis of procaine in the micellar media is attributed to the orientation of a reactive molecule to the surfactant and the binding constant of procaine with micelles. The rate of hydrolysis of procaine is negligible in DDTAB micelles. The observed results in the presence of cationic micelles were treated on the basis of the pseudophase ion exchange model. The results obtained in the presence of anionic micelles were treated by the pseudophase model, and the various kinetic parameters were determined.

A convenient laboratory synthesis of deuterium-labelled trimethyl tetradecyl ammonium sulphate

Chavda, Sameer,Coumbarides, Gregory S.,Dingjan, Marco,Eames, Jason,Zarbakhsh, Ali

, p. 147 - 151 (2007/10/03)

A convenient and practical laboratory synthesis of deuterium-labelled trimethyl tetradecyl ammonium sulphate is reported. Copyright

Interaction of Methyl Orange with Submicellar Cationic Surfactants

Dutta, Robin K.,Bhat, Subray N.

, p. 2457 - 2460 (2007/10/02)

The interaction of aqueous Methyl Orange (MO), an azo dye, with alkyltrimethylammonium and N-hexadecylpyridinium halide surfactants in submicellar concentration ranges has been investigated.The interaction gives rise to a new absorption band of MO with a maximum at ca. 370 nm, and the appearance of the new band has been attributed to change in the chromophore microenvironment in water structure enforced closely packed ion pairs of the dye with submicellar cationic surfactant.The strength of the interaction depends on the alkyl chain length of the surfactant, the surfactant head group and the counter ions.

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