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  • 108464-88-6 Structure
  • Basic information

    1. Product Name: 1,3-BIS(4-FLUOROBENZOYL)BENZENE
    2. Synonyms: 1,3-BIS(4-FLUOROBENZOYL)BENZENE;LABOTEST-BB LT00159359;1,3-BIS(4-FLUOROBENZ;1,3-Bis(4-Fluorobenzoyl)benzene (BFBZ);(4-fluorophenyl)({3-[(4-fluorophenyl)carbonyl]phenyl})Methanone;1,3-Phenylenebis((4-fluorophenyl)Methanone);1,3-Bis(4-Fluorobenzoyl;1,3-Bis(4-fluorobenzoyl)benzene 98%
    3. CAS NO:108464-88-6
    4. Molecular Formula: C20H12F2O2
    5. Molecular Weight: 322.3
    6. EINECS: 1312995-182-4
    7. Product Categories: C15 to C38;Carbonyl Compounds;Ketones
    8. Mol File: 108464-88-6.mol
    9. Article Data: 6
  • Chemical Properties

    1. Melting Point: 181-183 °C(lit.)
    2. Boiling Point: 476.3 °C at 760 mmHg
    3. Flash Point: 178.9 °C
    4. Appearance: /
    5. Density: 1.268
    6. Vapor Pressure: 3.08E-09mmHg at 25°C
    7. Refractive Index: 1.59
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1,3-BIS(4-FLUOROBENZOYL)BENZENE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,3-BIS(4-FLUOROBENZOYL)BENZENE(108464-88-6)
    12. EPA Substance Registry System: 1,3-BIS(4-FLUOROBENZOYL)BENZENE(108464-88-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 108464-88-6(Hazardous Substances Data)

108464-88-6 Usage

Description

1,3-Bis(4-fluorobenzoyl)benzene is an organic building block that is utilized in the synthesis of various polymers. It is characterized by its ability to polymerize with bisphenol-A in the presence of a solvent, such as N-methyl-2-pyrrolidinone, to produce high molecular weight polymers. 1,3-BIS(4-FLUOROBENZOYL)BENZENE is particularly useful in the development of copolymers with specific properties, such as sulfonated poly(aryl ether ketone)s (SPAEK), which have potential applications in different industries.

Uses

Used in Polymer Synthesis:
1,3-Bis(4-fluorobenzoyl)benzene is used as a monomer for the synthesis of high molecular weight polymers. Its incorporation into the polymer structure enhances the properties of the resulting material, making it suitable for various applications.
Used in the Chemical Industry:
1,3-Bis(4-fluorobenzoyl)benzene is used as an activated nonsulfonated difluoro-monomer for the synthesis of fluorenyl-containing sulfonated poly(aryl ether ether ketone ketone)s. These copolymers have potential applications in the chemical industry, where they can be utilized in the development of materials with specific properties, such as improved thermal stability, mechanical strength, and chemical resistance.
Used in the Development of Membrane Materials:
The sulfonated poly(aryl ether ketone)s (SPAEK) copolymers synthesized using 1,3-bis(4-fluorobenzoyl)benzene have potential applications in the development of membrane materials for fuel cells and other electrochemical applications. These copolymers exhibit excellent proton conductivity, thermal stability, and mechanical properties, making them ideal candidates for use in membrane materials.
Used in the Electronics Industry:
The high molecular weight polymers synthesized using 1,3-bis(4-fluorobenzoyl)benzene can also find applications in the electronics industry. These polymers can be used in the development of insulating materials, protective coatings, and other components that require high thermal stability, mechanical strength, and chemical resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 108464-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,4,6 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 108464-88:
(8*1)+(7*0)+(6*8)+(5*4)+(4*6)+(3*4)+(2*8)+(1*8)=136
136 % 10 = 6
So 108464-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H12F2O2/c21-17-8-4-13(5-9-17)19(23)15-2-1-3-16(12-15)20(24)14-6-10-18(22)11-7-14/h1-12H

108464-88-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-Phenylenebis((4-fluorophenyl)methanone)

1.2 Other means of identification

Product number -
Other names [3-(4-fluorobenzoyl)phenyl]-(4-fluorophenyl)methanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108464-88-6 SDS

108464-88-6Synthetic route

fluorobenzene
462-06-6

fluorobenzene

benzene-1,3-dicarbonyl dichloride
99-63-8

benzene-1,3-dicarbonyl dichloride

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Conditions
ConditionsYield
With aluminium trichloride at 23℃; for 4h; Friedel-Crafts acylation;98%
Stage #1: benzene-1,3-dicarbonyl dichloride With aluminum (III) chloride In dichloromethane for 0.5h; Friedel-Crafts Acylation; Inert atmosphere; Reflux;
Stage #2: fluorobenzene In dichloromethane for 12h; Friedel-Crafts Acylation; Inert atmosphere;
56%
Stage #1: benzene-1,3-dicarbonyl dichloride With aluminum (III) chloride In dichloromethane for 0.5h; Reflux;
Stage #2: fluorobenzene In dichloromethane for 12h; Reflux;
42%
With aluminum (III) chloride for 8h; Friedel-Crafts Acylation; Inert atmosphere;3.24 g
tris(4-fluorophenyl)bismuthane
437-29-6

tris(4-fluorophenyl)bismuthane

benzene-1,3-dicarbonyl dichloride
99-63-8

benzene-1,3-dicarbonyl dichloride

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Conditions
ConditionsYield
With triethylamine; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 3h;76%
With tributyl-amine In 1-methyl-pyrrolidin-2-one at 80℃; for 4h; Schlenk technique; Inert atmosphere;74%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; 4,4\-biphenol, 0.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; 4,4\-biphenol, 0.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; 4,4\-biphenol, 1 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; 4,4\-biphenol, 1 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; 4,4\-biphenol, 1.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; 4,4\-biphenol, 1.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; 4,4\-biphenol, 2 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; 4,4\-biphenol, 2 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; 4,4\-biphenol, 2.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; 4,4\-biphenol, 2.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 4 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 4 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

hydroquinone
123-31-9

hydroquinone

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; hydroquinone, 0.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; hydroquinone, 0.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

hydroquinone
123-31-9

hydroquinone

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; hydroquinone, 1 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; hydroquinone, 1 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

hydroquinone
123-31-9

hydroquinone

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; hydroquinone, 1.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; hydroquinone, 1.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

hydroquinone
123-31-9

hydroquinone

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; hydroquinone, 2 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; hydroquinone, 2 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt
135-53-5

2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

hydroquinone
123-31-9

hydroquinone

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; hydroquinone, 2.5 mmol

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; hydroquinone, 2.5 mmol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;100%
indole
120-72-9

indole

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C36H24N2O2
1515716-88-7

C36H24N2O2

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160℃; for 4h; Schlenk technique; Inert atmosphere;95%
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-bis(3-nitro-4-fluorobenzoyl)benzene

1,3-bis(3-nitro-4-fluorobenzoyl)benzene

Conditions
ConditionsYield
With sulfuric acid; nitric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate87.3%
3-mercaptothiophenol
626-04-0

3-mercaptothiophenol

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C26H16O2S2

C26H16O2S2

Conditions
ConditionsYield
With potassium carbonate In hexane; N,N-dimethyl acetamide for 18h; Heating;75%
m-Hydroxyaniline
591-27-5

m-Hydroxyaniline

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-bis[4-(3-aminophenoxy)benzoyl]benzene
110471-15-3

1,3-bis[4-(3-aminophenoxy)benzoyl]benzene

Conditions
ConditionsYield
Stage #1: m-Hydroxyaniline With potassium carbonate In N,N-dimethyl-formamide; toluene Dean-Stark trap; Reflux;
Stage #2: 1,3-bis(4'-fluorobenzoyl)benzene In N,N-dimethyl-formamide; toluene at 130 - 150℃; Inert atmosphere;
64.4%
sodium acetylide
1066-26-8

sodium acetylide

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-di[1-hydroxy-1-(p-fluorophenyl)-prop-2-ynyl]benzene
874365-01-2

1,3-di[1-hydroxy-1-(p-fluorophenyl)-prop-2-ynyl]benzene

Conditions
ConditionsYield
With acetylene In tetrahydrofuran; dimethyl sulfoxide at 23℃;64%
(S)-[1,1']-binaphthalenyl-2,2'-diol
18531-99-2

(S)-[1,1']-binaphthalenyl-2,2'-diol

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C60H36O6F2

C60H36O6F2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 9h;64%
thiosemicarbazide
79-19-6

thiosemicarbazide

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-bis-(4-fluorobenzoyl)benzene thiosemicarbazone
1458033-39-0

1,3-bis-(4-fluorobenzoyl)benzene thiosemicarbazone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol for 10h; Reflux;52%
With toluene-4-sulfonic acid In methanol for 10h; Inert atmosphere; Reflux;52%
4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

A

C64H40O8

C64H40O8

B

TIMEOUT: 5s

TIMEOUT: 5s

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene for 8h; Cyclo-condensation; Heating;A 7.7%
B 15%
9H-carbazole
86-74-8

9H-carbazole

1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-phenylenebis(4-(9H-carbazol-9-yl)phenyl)methanone

1,3-phenylenebis(4-(9H-carbazol-9-yl)phenyl)methanone

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere;12%
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C40H26N4O5
599205-75-1

C40H26N4O5

polymer, Mn 16824 by GPC, Mw 36525, ηinh 0.68 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-dihydroxydiphenyl ether

polymer, Mn 16824 by GPC, Mw 36525, ηinh 0.68 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-dihydroxydiphenyl ether

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C40H26N4O3S2

C40H26N4O3S2

polymer, Mn 63403 by GPC, Mw 151167, ηinh 1.01 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-oxybis(benzenethiol)

polymer, Mn 63403 by GPC, Mw 151167, ηinh 1.01 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-oxybis(benzenethiol)

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C43H32N4O4
599205-73-9

C43H32N4O4

polymer, Mn 37852 by GPC, Mw 93547, ηinh 0.91 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-isopropylidenebiphenol

polymer, Mn 37852 by GPC, Mw 93547, ηinh 0.91 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-isopropylidenebiphenol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C43H26F6N4O4
599205-74-0

C43H26F6N4O4

polymer, Mn 31112 by GPC, Mw 55299, ηinh 0.41 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-(hexafluoroisopropylidene)biphenol

polymer, Mn 31112 by GPC, Mw 55299, ηinh 0.41 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-(hexafluoroisopropylidene)biphenol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

C80H48O8

C80H48O8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / potassium carbonate / dimethylformamide / 9 h / 150 °C
2: 2 percent / potassium carbonate / toluene; dimethylformamide / 108 h / 150 °C
View Scheme
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-di-(3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene
874365-05-6

1,3-di-(3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C
2: 73 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 6 h / Heating
View Scheme
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-di-(8-bromo-3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene
874365-10-3

1,3-di-(8-bromo-3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C
2: 86 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 8 h / Heating
View Scheme
1,3-bis(4'-fluorobenzoyl)benzene
108464-88-6

1,3-bis(4'-fluorobenzoyl)benzene

1,3-di-(2-p-fluorophenyl-6-phenyl-5-ethoxycarbonyl-[2H]-naphtho[2,1-b]pyran-2-yl)-benzene
874365-15-8

1,3-di-(2-p-fluorophenyl-6-phenyl-5-ethoxycarbonyl-[2H]-naphtho[2,1-b]pyran-2-yl)-benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C
2: 72 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 6 h / Heating
View Scheme

108464-88-6Relevant articles and documents

Diversified AIE and mechanochromic luminescence based on carbazole derivative decorated dicyanovinyl groups: Effects of substitution sites and molecular packing

Guo, Zhiyong,Han, Mingxi,Qian, Li,Wang, Kai,Wu, Xianfeng,Xiao, Hui,Zhan, Hongbing

, p. 2166 - 2172 (2020)

Aggregation-induced emission (AIE) properties have been widely investigated not only because they thoroughly circumvent the notorious aggregation-caused quenching effect encountered in conventional fluorophores but also due to their promising applications in organic light-emitting diodes, fluorescent sensors and bioimaging. In this work, we reported a study of the molecular packing and luminescence properties of AIE active positional isomers (m-BPCDM and p-BPCDM) with carbazole and dicyanovinyl groups. The compound m-BPCDM based on meta-substitution showed more evident AIE processes than the compound p-BPCDM based on para-substitution, which can be attributed to the strong π-π stacking effect brought by the spatial structure of p-BPCDM. Moreover, the two positional isomers also exhibited distinct mechanochromic luminescence properties.

COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS

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Paragraph 0133, (2013/10/08)

This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

Atom-efficient cross-coupling reactions of triarylbismuths with acyl chlorides under Pd(0) catalysis

Rao, Maddali L.N.,Venkatesh, Varadhachari,Banerjee, Debasis

, p. 12917 - 12926 (2008/03/28)

The atom-efficient cross-coupling reaction of triarylbismuths with a variety of aliphatic, aromatic, and hetero-aromatic acyl chlorides was demonstrated to afford high yields of cross-coupled ketones under palladium catalysis. The corresponding cross-coupling reaction with diacid chlorides also furnished bis-coupled ketones in good yields.

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