108310-92-5

Basic information

• Product Name: Guanosine, 2'-deoxy-6-O-[2-(4-nitrophenyl)ethyl]-, 3',5'-diacetate
• CAS NO: 108310-92-5
• Molecular Formula: C22H24N6O8
• Molecular Weight: 500.468
• Mol File: 108310-92-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Guanosine, 2'-deoxy-6-O-[2-(4-nitrophenyl)ethyl]-, 3',5'-diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine, 2'-deoxy-6-O-[2-(4-nitrophenyl)ethyl]-, 3',5'-diacetate(108310-92-5)
• EPA Substance Registry System: Guanosine, 2'-deoxy-6-O-[2-(4-nitrophenyl)ethyl]-, 3',5'-diacetate(108310-92-5)

Safety Data

• Hazardous Substances Data: 108310-92-5(Hazardous Substances Data)

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 69992-10-5 3',5'-di-O-acetyl-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 

Downstream Products

• 233756-58-6 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester 
• 1080623-91-1 3'-O-acetyl-2'-deoxy-2-fluoro-O₆-[2-(4-nitrophenyl)ethyl]inosine 
• 148144-84-7 2'-deoxy-3'-O-<2-(2,4-dinitrophenyl)ethoxycarbonyl>-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 
• 148144-81-4 2'-deoxy-5'-O-(monomethoxytrityl)-N²,3'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 

Relevant articles and documents

2’-DEOXYGUANOSINE HYBRID COMPOUND CONTAINING PYRROLE AMIDE TETRAMER, METHOD OF PRODUCING THE SAME AND PRODUCTION INTERMEDIATE THEREFOR

It is intended to provide an MGB polyamide hybrid compound which has a function of recognizing a base sequence useful in gene therapy, is efficacious in synthesizing an oligomer and has a high stability. An MGB polyamide hybrid compound represented by the following formula (38) which is characterized by being a pyrrole amide tetramer prepared by introducing a 1-methylpyrrole-2-carbonyl group as a substitute for the N-terminal formyl group in the existing case.

New 2-(4-nitrophenyl)ethyl(Npe)- and 2-(4- nitrophenyl)ethoxycarbonyl(Npeoc)protected 2'-deoxyribonucleosides and their 3'-phosphoramidites - Versatile building blocks for oligonucleotide synthesis

A series of new base-protected and 5'-O-(4-monomethoxytrityl)- or 5'-O- (4,4'-dimethoxytrityl)-substituted 3'-(2-cyanoethyl diisopropylphosphoramidites) and 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidites] 52-66 and 67-82, respectively, are prepare

Nucleosides. Part LI. The 2-(4-Nitrophenyl)ethoxycarbonyl (npeoc) and 2-(2,4-Dinitrophenyl)ethoxycarbonyl (dnpeoc) Groups for Protection of Hydroxy Functions in Ribonucleosides and 2'-Deoxyribonucleosides

The common 2'-deoxypyrimidine and -purine nucleosides, thymidine (4), O4-thymidine (17), 2'-deoxy-N4-cytidine (26), 2'-deoxy-N6-adenosine (39), and 2'-deoxy-N2--O6-guanosine (52) were further protected by the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) and the 2-(2,4-dinitrophenyl)ethoxycarbonyl (dnpeoc) group at the OH functions of the sugar moiety to form new partially and fully blocked intermediates for nucleoside and nucleotide syntheses.The corresponding 5'-O-monomethoxytrityl derivatives 5, 18, 30, 40, and 56 were also used as starting material to synthesize some other intermediates which were not obtained by direct acylations.In the ribonucleoside series, the 5'-O-monomethoxytrityl derivatives 14, 36, 49, and 63 reacted with 2-(4-nitrophenyl)ethyl chloroformate (1) to the corresponding 2',3'-bis-carbonates 15, 37, 50, and 64 which were either detritylated to 16, 38, 51, and 65, respectively, or converted by 1,8-diazabicycloundec-7-ene (DBU) treatment to the 2',3'-cyclic carbonates 66-69.The newly synthesized compounds were characterized by elemental analyses and UV and 1H-NMR spectra.