1072930-86-9Relevant articles and documents
Preparation method of sarpogrelate hydrochloride intermediate
-
Paragraph 0039; 0057-0069, (2017/11/29)
The invention discloses a preparation method of sarpogrelate hydrochloride intermediate (2-hydroxy-3'-methoxy diphenylethane). According to the preparation method, m-bromoanisole, ethane, and o-benzyloxybromobenzene are taken as initial raw materials, an inorganic base is taken as an auxiliary agent, a palladium catalyst is adopted for catalysis, and o-benzoxy-3'-methoxy toluylene is obtained via reaction; o-benzoxy-3'-methoxy toluylene is subjected to hydrogenation debenzylation so as to obtain 2-hydroxy-3'-methoxy diphenylethane. The raw materials are common chemical raw materials, are cheap, and are high in safety; separation of by-products obtained in reaction process is relatively simple; separation is complete; steps are few; on-pot-method is adopted; and product yield is increased.
Synthesis method of 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene
-
Paragraph 0020;0021, (2016/11/14)
The invention provides a method for synthesizing 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene. The method comprises the following steps: making diphenylmethoxyphosphine react with m-methoxybenzyl chloride at 55-60 DEG C to obtain m-methoxybenzyldiphenylphosphine oxide; adding a solvent and a basifier into the m-methoxybenzyldiphenylphosphine oxide; and keeping reactions at room temperature to obtain 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene. The synthesis preparation method is simple, mild in reaction and easy to implement.
New method for synthesizing 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene
-
Paragraph 0024; 0025, (2016/11/24)
The invention provides a new method for synthesizing 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene. The method comprises the following steps: adding diphenylmethoxyphosphine and m-methoxybenzyl chloride in a molar ratio of 1:(1-1.2) into a reaction device; heating to 55-60 DEG C while stirring, and keeping reactions for 10-12h at the temperature; after the reactions, cooling to room temperature to obtain m-methoxybenzyldiphenylphosphine oxide; adding a solvent and a basifier into the m-methoxybenzyldiphenylphosphine oxide, controlling the temperature at 10-20 DEG C and further dropwise adding the solvent; preserving heat for 5-8h at 10-20 DEG C; performing reduced-pressure recovery of the solvent to dryness, and adding water and stirring and filtering; and washing the material to neutrality and drying at 55-60 DEG C to obtain 1-benzyloxy-2-[2-(3-methoxyphenyl)vinyl]benzene. The synthesis preparation method is simple, mild in reactionand easy to implement.