1068-42-4Relevant articles and documents
Crystal structures of mono-, Di-, and triaminoguanidinium sulfate, as well as azidoformamidinium sulfate: Important precursors for syntheses of nitrogen rich ionic vompounds
Klapoetke, Thomas M.,Mayer, Peter,Stierstorfer, Joerg
, p. 2393 - 2407 (2009)
Bis(1-aminoguanidinium) sulfate monohydrate (AG2SO4 H2O, 1), bis(1,3-diamino-guanidinium sulfate (DAG2SO 4, 2), bis(1,3,5-triaminoguanidinium) sulfate dihydrate (TAG 2SO4 2 Hsub
Improved synthesis process for lamotrigine
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Paragraph 0032, (2017/07/21)
The invention discloses an improved synthesis process for lamotrigine. The process comprises the following steps: (1) synthesizing 2,3-dichlorobenzoyl cyanide: adding 2,3-dichlorobenzoic acid and thionyl chloride into a reactor, carrying out depressurized evaporating to remove thionyl chloride after a reaction is completed, adding cuprous cyanide into the reactor, and filtering out solids after a reaction is completed, so as to obtain a 2,3-dichlorobenzoyl cyanide solution; (2) preparing a condensate: adding aminoguanidine carbonate and an entrainer into a reactor, dropwise adding concentrated sulfuric acid, distilling off the entrainer and water, carrying out suction filtration, enabling solids to enter a reaction bottle, carrying out depressurized pumping, then, adding the 2,3-dichlorobenzoyl cyanide solution obtained in the step (1) into the reaction bottle, cooling the reaction bottle to room temperature after a reaction is completed, and carrying out suction filtration, so as to obtain the condensate; and (3) preparing cyclics: adding liquid alkali into the condensate obtained in the step (2), and carrying out crystallizing, filtering, washing and baking after a reaction, thereby obtaining the lamotrigine. According to the improved synthesis process for the lamotrigine, the quality and yield of the product, i.e., the lamotrigine can be remarkably increased, and the yield reaches 90% or more.
The synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5a(14C)] pyrimidine-2-carbaldehyde from [14C]aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate
Rane, Anil M.,Klaas, Schildknegt
scheme or table, p. 257 - 260 (2011/05/06)
Hydrazination of barium [14C]cyanamide and hydrazinolysis of S-methylisothio[14C]urea were compared for their ability to efficiently prepare [14C]aminoguanidine bicarbonate. [ 14C]Aminoguanidine bicarbonate was converted in three steps to 5, 7-dimethyl-1,2,4-triazolo[1,5a(14C)]pyrimidine-2-carbaldehyde, a key radiochemical GMP starting material. Copyright