106675-70-1Relevant articles and documents
Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides
Gediya, Shweta K.,Vyas, Vijyesh K.,Clarkson, Guy J.,Wills, Martin
supporting information, p. 7803 - 7807 (2021/10/20)
The asymmetric transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which lead to the highest enantioselectivities in the products. The α-keto-amide reduction products have been converted to a range of synthetically valuable derivatives.
One-pot transition-metal-free synthesis of weinreb amides directly from carboxylic acids
Niu, Teng,Wang, Ke-Hu,Huang, Danfeng,Xu, Changming,Su, Yingpeng,Hu, Yulai,Fu, Ying
, p. 320 - 330 (2014/02/14)
Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60 °C in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]3 in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production. Georg Thieme Verlag KG Stuttgart · New York.
METHOD FOR PRODUCING N,N -DIALKOXY-N,N -DIALKYL OXAMIDE
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Page/Page column 5, (2008/06/13)
The present invention provides a process for preparing an N,N'-dialkoxy-N,N'-dialkyl oxamide represented by the formula (3) : wherein R2 and R3 may be the same or different from each other, and each represent an alkyl group having 1 to 4 carbon atoms, which comprises reacting an oxalic acid diester represented by the formula (1): wherein R1 and R1' may be the same or different from each other, and each represent a hydrocarbon group, and an N-alkyl-O-alkylhydroxylamine represented by the formula (2): ????????R2O-NHR3?????(2) wherein R2 and R3 have the same meanings as defined above, or an acid salt thereof in the presence of a base.