1063877-16-6

Basic information

• Product Name: C₂₀H₃₂O
• CAS NO: 1063877-16-6
• Molecular Weight: 288.473
• Mol File: 1063877-16-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₃₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₃₂O(1063877-16-6)
• EPA Substance Registry System: C₂₀H₃₂O(1063877-16-6)

Safety Data

• Hazardous Substances Data: 1063877-16-6(Hazardous Substances Data)

Upstream product

• 85562-26-1 [4-(6-Bromohexyl)butyl]benzene 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 1064016-68-7 (2S,4R)-2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone 

Relevant articles and documents

A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16- phenylhexadecanoic acid 1,4-lactone and its PPAR activities

A novel class of natural PPAR agonists, 2,4-dimethyl-4-hydroxy-16- phenylhexadecanoic acid 1,4-lactone (1), were discovered in marine natural product libraries. The synthesis of 1 was accomplished starting from vinylmethyl ketone. Ring formation of the α,γ dialkyl γ-lactone was achieved via the stereo-controlled reaction of a ketyl radical anion with a chiral methacrylate. In the PPAR agonistic assay, the most potent of the four stereoisomers had EC50 values of 12 μM for mPPARα, 9 μM for mPPARδ and >100 μM for mPPARγ.