106146-95-6Relevant articles and documents
Asymmetric syntheses of (+)-diltiazem hydrochloride
Watson, Keith G.,Fung, Yik M.,Gredley, Matthew,Bird, Graham J.,Jackson, W. Roy,Gountzos, Helen,Matthews, Barry R.
, p. 1018 - 1019 (2007/10/02)
Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.